EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
1.1.1.324 | (6E)-8-hydroxygeraniol + 2 NADP+ |
- |
Rauvolfia serpentina |
(6E)-8-oxogeranial + 2 NADPH + 2 H+ |
- |
r |
1.1.1.324 | (6E)-8-hydroxygeraniol + 2 NADP+ |
- |
Nepeta racemosa |
(6E)-8-oxogeranial + 2 NADPH + 2 H+ |
- |
? |
1.1.1.324 | (6E)-8-hydroxygeraniol + 2 NADP+ |
10-hydroxygeraniol undergoes a reversible dehydrogenation to produce 8-oxogeraniol or 8-hydroxygeranial, which are oxidized further to give 8-oxogeranial, the direct precursor of iridodial |
Rauvolfia serpentina |
(6E)-8-oxogeranial + 2 NADPH + 2 H+ |
- |
r |
1.1.1.324 | (6E)-8-hydroxygeraniol + 2 NADP+ |
oxidization at C1 and C8, depending on numbering of the molecule, GC-MS product analysis |
Nepeta racemosa |
(6E)-8-oxogeranial + 2 NADPH + 2 H+ |
- |
? |
1.1.1.324 | (6E)-8-hydroxynerol + 2 NADP+ |
- |
Rauvolfia serpentina |
? + 2 NADPH + 2 H+ |
- |
r |
1.1.1.324 | (6E)-8-hydroxynerol + 2 NADP+ |
- |
Nepeta racemosa |
? + 2 NADPH + 2 H+ |
- |
? |
1.1.1.324 | (6E)-8-hydroxynerol + 2 NADP+ |
oxidization at C1 and C8, depending on numbering of the molecule, GC-MS product analysis |
Nepeta racemosa |
? + 2 NADPH + 2 H+ |
- |
? |
1.1.1.324 | geraniol + 2 NADP+ |
- |
Rauvolfia serpentina |
? + 2 NADPH + 2 H+ |
- |
r |
1.1.1.324 | more |
various branched-chain allylic primary alcohols, such as nerol, geraniol, and 8-hydroxygeraniol, are substrates, but ethanol is inert. The enzyme is also active with farnesol, 3-methyl-2-buten1-ol, citronellol, 4-isopropylbenzyl alcohol, trans-2-heptenol, and trans-2-hexenol. The enzyme exclusively transfers the pro-R hydrogen of NADPH to neral. No activity with linalool, 2,6-dimethyl-octane, iridodial, 1-octanol, 1-heptanol, 1-pentanol, 3-methyl-3-buten-1-ol, trans-crotyl alcohol, isopulegol, and menthol |
Rauvolfia serpentina |
? |
- |
? |
1.1.1.324 | nerol + 2 NADP+ |
- |
Rauvolfia serpentina |
? + 2 NADPH + 2 H+ |
- |
r |