EC Number   |
Substrates |
Products  |
Reversibility |
|---|
    1.1.1.218 | nalorphine + NAD(P)+ |
best substrate, oxidation at 120% the rate of morphine oxidation |
(5alpha)-3-hydroxy-17-(prop-2-en-1-yl)-7,8-didehydro-4,5-epoxymorphinan-6-one + NAD(P)H + H+ |
- |
? |
| 1.1.1.218 | 1-indanol + NADP+ |
- |
1-indanone + NADPH |
- |
? |
| 1.1.1.218 | naloxone + NAD(P)H |
- |
6alpha-naloxol + NADP+ |
stereospecific reduction |
? |
| 1.1.1.218 | 3-hydroxyhexobarbital + NADP+ |
does not serve as a substrate for guinea pig enzyme |
? |
- |
? |
| 1.1.1.218 | benzenedihydrodiol + NADP+ |
- |
? |
- |
? |
| 1.1.1.218 | ethylmorphine + NAD(P)+ |
- |
? |
- |
? |
| 1.1.1.218 | ethylmorphine + NAD(P)+ |
oxidation at 51% the rate of morphine oxidation |
? |
- |
? |
| 1.1.1.218 | more |
the enzyme AKR1C34 shows 3alpha/17beta/20alpha-hydroxysteroid dehydrogenase activities, EC 1.1.1.239, detailed overview. Ala54 plays a critical role in non-/recognition of the steroidal substrates. Reaction products identification by thin-layer chromatography (TLC) and liquid chromatography/mass spectrometry (LC/MS) |
? |
- |
? |
| 1.1.1.218 | more |
the enzyme shows NAD+-dependent dehydrogenase activity towards other nonsteroidal alicyclic alcohols and 3alpha/17beta-hydroxy-C18/C19/C21-steroids, detailed overview |
? |
- |
? |
| 1.1.1.218 | morphine + NAD+ |
- |
? |
- |
? |
