EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
6.3.4.2 | ATP + UTP + glutamine |
- |
Escherichia coli |
ADP + phosphate + CTP + Glu |
- |
? |
6.3.4.2 | ATP + UTP + glutamine |
- |
Saccharomyces cerevisiae |
ADP + phosphate + CTP + Glu |
- |
? |
6.3.4.2 | ATP + UTP + glutamine |
- |
Bos taurus |
ADP + phosphate + CTP + Glu |
- |
? |
6.3.4.2 | ATP + UTP + glutamine |
- |
Lactococcus lactis |
ADP + phosphate + CTP + Glu |
- |
? |
6.3.4.2 | ATP + UTP + glutamine |
maximal activity with NH4+ is at least 20% greater than with glutamine |
Escherichia coli |
ADP + phosphate + CTP + Glu |
- |
? |
6.3.4.2 | ATP + UTP + glutamine |
maximal activity with NH4+ is at least 20% greater than with glutamine |
Escherichia coli B / ATCC 11303 |
ADP + phosphate + CTP + Glu |
- |
? |
6.3.4.2 | ATP + UTP + glutamine |
- |
Homo sapiens |
ADP + phosphate + CTP + L-glutamate |
- |
? |
6.3.4.2 | ATP + UTP + glutamine |
- |
Saccharomyces cerevisiae |
ADP + phosphate + CTP + L-glutamate |
- |
? |
6.3.4.2 | ATP + UTP + glutamine |
CTP synthetase is a cytosolic-associated glutamine amidotransferase enzyme that catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to the C-4 position of UTP to form CTP. CTP is an essential precursor of all membrane phospholipids that are synthesized via the Kennedy, i.e. CDP-choline and CDP-ethanolamine branches, and CDP-diacylglycerol pathways. The URA7-encoded CTP synthetase is responsible for the majority of the CTP made in vivo. Regulation mechanisms, detailed overview |
Saccharomyces cerevisiae |
ADP + phosphate + CTP + L-glutamate |
- |
? |
6.3.4.2 | ATP + UTP + glutamine |
the CTPS1-encoded enzyme is regulated by reversible phosphorylation at Thr455, regulation mechanisms, overview |
Homo sapiens |
ADP + phosphate + CTP + L-glutamate |
- |
? |