EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.24.B6 | amelogenin + H2O |
- |
Homo sapiens |
? |
- |
? |
| 3.4.24.B6 | amelogenin + H2O |
- |
Sus scrofa |
? |
- |
? |
| 3.4.24.B6 | amelogenin + H2O |
- |
Bos taurus |
? |
- |
? |
| 3.4.24.B6 | amelogenin + H2O |
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis |
Homo sapiens |
? |
- |
? |
| 3.4.24.B6 | amelogenin + H2O |
amelogenin with a proline 41 to threonine mutation is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis imperfecta. P41T mutation reduces the interactions between amelogenin and MMP20, leading to decreased degradation of amelogenin by MMP20, and resulting in amelogenesis imperfecta |
Homo sapiens |
? |
- |
? |
| 3.4.24.B6 | amelogenin + H2O |
cleavage loci: FSY/EVL, GGW/LHH, MFP/MQP, MLP/DLT, DLT/LEA, LTL/EAW, AWP/STD |
Homo sapiens |
? |
- |
? |
| 3.4.24.B6 | amelogenin + H2O |
cleavage loci: FSY/EVL, GGW/LHH, MFP/MQP, MLP/DLT, LTL/EAW, AWP/STD |
Bos taurus |
? |
- |
? |
| 3.4.24.B6 | amelogenin + H2O |
amelogenin constitutes more than 90% of enamel extracellular matrix proteins in secretory-stage enamel |
Sus scrofa |
? |
- |
? |
| 3.4.24.B6 | amelogenin + H2O |
MMP-20 is involved in amelogenin processing and degradation |
Mus musculus |
? |
- |
? |
| 3.4.24.B6 | amelogenin + H2O |
most of the secreted substrate is cleaved after Ser148 to generate the 20000 Da amelogenin (Met1-Ser148), which in turn is cleaved after Trp45 to yield the tyrosine-rich amelogenin polypeptide (Met1-Trp45) and the 13000 Da amelogenin (Leu46-Ser148) |
Sus scrofa |
? |
- |
? |
