EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.23.B24 | sterol regulatory element-binding protein + H2O |
SrbA is sequentially cleaved by Dsc complex-linked proteolysis and SppA |
Aspergillus nidulans A773 |
? |
- |
? |
| 3.4.23.B24 | TfR 1 + H2O |
intramembrane cleavage sites |
Mus musculus |
? |
- |
? |
| 3.4.23.B24 | TNF-alpha + H2O |
intramembrane cleavage sites |
Mus musculus |
? |
- |
? |
| 3.4.23.B24 | unfolded protein response regulator XBP1u + H2O |
- |
Homo sapiens |
? |
cleavage occurs within a so far unrecognized type II transmembrane domain, which renders XBP1u as an signal peptide peptidase substrate through specific sequence features |
? |
| 3.4.23.B24 | XBP1 + H2O |
the isolated XBP1u hydrophobic region and the isolated transmembrane domain (TDM) region with N-terminal flanking residues of the enzyme interact, positional effect of di-glycine motifs of XBP1u on SPP-catalyzed turnover. Enzyme activity with diverse substrate mutants, overview |
Homo sapiens |
? |
- |
? |
| 3.4.23.B24 | XBP1u + H2O |
turnover of XBP1u is governed by its transmembrane domain |
Homo sapiens |
? |
- |
? |
