EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.23.48 | plasminogen + H2O |
activation |
Yersinia pestis |
plasmin + ? |
- |
? |
| 3.4.23.48 | plasminogen + H2O |
plasminogen activator is a surface virulence factor that contributes to the highly imvasive nature of the pathogen by binding various tissue matrix components |
Yersinia pestis |
plasmin + ? |
- |
? |
| 3.4.23.48 | plasminogen + H2O |
cleavage of Arg560-/-Val561 |
Yersinia pestis |
plasmin + ? |
- |
? |
| 3.4.23.48 | plasminogen + H2O |
capacity to convert plasminogen into plasmin by the action of the outer-membrane Lpa protein determined |
Legionella pneumophila |
plasmin + ? |
- |
? |
| 3.4.23.48 | plasminogen + H2O |
identification and analysis of small-peptide substrates and inhibitors of plasminogen activator Pla by use of parallel synthesis and positional scanning |
Yersinia pestis |
plasmin + ? |
- |
? |
| 3.4.23.48 | plasminogen + H2O |
plasminogen activator Pla shown to be essential to cause primary pneumonic plague, minor importance determined for dissemination during pneumonic plague than during bubonic plague, inhibition of plasminogen activator Pla expression shown to prolong survival of infected mice |
Yersinia pestis |
plasmin + ? |
- |
? |
| 3.4.23.48 | plasminogen + H2O |
capacity to convert plasminogen into plasmin by the action of the outer-membrane Lpa protein determined |
Legionella pneumophila Philadelphia |
plasmin + ? |
- |
? |
| 3.4.23.48 | plasminogen activator inhibitor-1 + H2O |
- |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | plasminogen activator inhibitor-1 + H2O |
inactivation |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | plasminogen activator inhibitor-1 + H2O |
inactivation. PAI-1 is the primary physiological inhibitor of uPA and t-PA and a major inhibitor of fibrinolysis. Pla rapidly inactivates PAI-1 by a single cleavage of the bait peptide at R346-M347. In circulation, most PAI-1 is bound to vitronectin, which is also degraded by Pla |
Yersinia pestis |
? |
- |
? |
