EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.23.48 | complement protein C3 + H2O |
- |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | D-Val-Leu-Lys-p-nitroanilide + H2O |
Lpa gene encoding a homologue of the plasminogen activator Pla of Yersinia pestis identified, described as a surface protease exhibiting plasminogen activator activity, plasminogen activity of inner and outer membranes measured |
Legionella pneumophila |
D-Val-Leu-Lys + p-nitroaniline |
- |
? |
| 3.4.23.48 | D-Val-Leu-Lys-p-nitroanilide + H2O |
Lpa gene encoding a homologue of the plasminogen activator Pla of Yersinia pestis identified, described as a surface protease exhibiting plasminogen activator activity, plasminogen activity of inner and outer membranes measured |
Legionella pneumophila Philadelphia |
D-Val-Leu-Lys + p-nitroaniline |
- |
? |
| 3.4.23.48 | human alpha2-antiplasmin + H2O |
- |
Yersinia pestis |
fragments of alpha2-antiplasmin |
- |
? |
| 3.4.23.48 | human Glu-plasminogen + H2O |
Pla activates Glu-plasminogen to plasmin, in vitro, TFPI is found to be a much better substrate for Pla than plasminogen |
Yersinia pestis |
plasmin + ? |
- |
? |
| 3.4.23.48 | human tissue factor pathway inhibitor + H2O |
Pla can proteolytically degrade TFPI, completely abrogating its anticoagulant function. In vitro, TFPI is found to be a much better substrate for Pla than plasminogen |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | more |
plasminogen activator Pla is essential for the spread of Yersinia pestis from the subcutaneous infection site into circulation, and the proteolytic activation of plasminogen is involved in virulence function. In addition to proteolysis plasminogen activator Pla promotes bacterial adhesion to mammalian extracellular matrices and epithelial cells as well as bacterial invasion into eukayotic cells. Laminin functions as an adhesion target for plasminogen activator Pla, which also expresses a lower adhesion affinity for heparan sulfate proteoglycan. the adhesion targets are not directly degraded by plasminogen activator Pla, but Pla-mediated generation of plasmin leads to their degradation |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | more |
plasminogen activator plays a pivotal role in internalisation of bacteria by HeLa cells. Intracellular signalling and cytoskeletal rearrangement is involved in Yersinia pestis plasminogen activator mediated HeLa cell invasion |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | more |
no degradation of Val-Leu-Lys-p-nitroanilide. Plasminogen activator degrades outer membrane proteins of Yersinia cell surface and exhibits a weak coagulase activity. In addition to proteolysis plasminogen activator Pla promotes bacterial adhesion to mammalian extracellular matrices and epithelial cells as well as bacterial invasion into eukaryotic cells. Laminin functions as an adhesion target for plasminogen activator Pla, which also expresses a lower adhesion affinity for heparan sulfate proteoglycan. The adhesion targets are not directly degraded by plasminogen activator Pla, but Pla-mediated generation of plasmin leads to their degradation |
Yersinia pestis |
? |
- |
? |
| 3.4.23.48 | more |
the enzyme performs autoproteolysis |
Yersinia pestis subsp. microtus |
? |
- |
? |
