EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.23.38 | hemoglobin alpha-chain + H2O |
cleavage of the Phe33-/-Leu34- bond |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.38 | hemoglobin beta-chain + H2O |
cleavage sites: Leu31-/-Leu32, Phe41-/-Phe43, Ala129-/-Tyr130 |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.38 | hemoglobin alpha-chain + H2O |
cleavage sites: Phe33-/-Leu34, Phe46-/-Asp47, Phe98-/-Lys99 |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.38 | Hemoglobin + H2O |
during the infection of erythrocytes by the human malaria parasite Plasmodium falciparum, up to 80% of the host cell hemoglobin is degraded to provide amino acids for parasite nutrition. Plasmepsin I and plasmepsin II are believed to be responsible for initiating the catabolic process |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.38 | Hemoglobin + H2O |
enzyme is involved in initial steps of Plasmodium hemoglobin degradation |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.38 | more |
plasmepsin I is 5 to 9times less effective than plasmepsin II at cleaving substrates which mimic the proposed initial cleavage site in the alpha-chain of hemoglobin |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.38 | more |
plasmepsin I is synthesized and processed to the mature form soon after the parasite invades the red blood cell |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.38 | more |
S1' subsite prefers hydrophobic residues and the S2' subsite shifts its preferences more to polar residues. Serine is a preferred P1' substitution |
Plasmodium falciparum |
? |
- |
? |
| 3.4.23.38 | Hemoglobin + H2O |
the enzyme initiates the hemoglobin degradation pathway in Plasmodium |
Plasmodium falciparum |
? |
- |
? |
