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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
3.4.23.38
Lys-Glu-Phe-Asn-Phe-Phe(NO2)-Ala-Leu-Lys + H2O
-
Plasmodium falciparum
Lys-Glu-Phe-Asn-Phe + Phe(NO2)-Ala-Leu-Lys
-
?
3.4.23.38
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O
-
Plasmodium falciparum
Lys-Glu-Phe-Val-Phe + Phe(NO2)-Ala-Leu-Lys
-
?
3.4.23.38
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Arg-Leu-Lys + H2O
-
Plasmodium falciparum
Lys-Glu-Phe-Val-Phe + Phe(NO2)-Arg-Leu-Lys
-
?
3.4.23.38
Lys-Pro-Ile-Leu-Phe-(p-nitro)Phe-Arg-Leu + H2O
-
Plasmodium falciparum
Lys-Pro-Ile-Leu-Phe + (p-nitro)Phe-Arg-Leu
-
?
3.4.23.38
Lys-Pro-Ile-Leu-Phe-Nph-Arg-Leu + H2O
-
Plasmodium falciparum
?
-
?
3.4.23.38
Lys-Pro-Ile-Lys-Phe-Phe(NO2)-Arg-Leu + H2O
-
Plasmodium falciparum
Lys-Pro-Ile-Lys-Phe + Phe(NO2)-Arg-Leu
-
?
3.4.23.38
more
plasmepsin I is 5 to 9times less effective than plasmepsin II at cleaving substrates which mimic the proposed initial cleavage site in the alpha-chain of hemoglobin
Plasmodium falciparum
?
-
?
3.4.23.38
more
plasmepsin I is synthesized and processed to the mature form soon after the parasite invades the red blood cell
Plasmodium falciparum
?
-
?
3.4.23.38
more
S1' subsite prefers hydrophobic residues and the S2' subsite shifts its preferences more to polar residues. Serine is a preferred P1' substitution
Plasmodium falciparum
?
-
?
Results
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