EC Number   |
Substrates  |
Organism |
Products |
Reversibility |
|---|
   3.4.21.B30 | more |
the damage-induced RecA:ssDNA nucleoprotein filament facilitates autocleavage of the N-terminal 24-amino acids of UmuD2 to yield UmuD'2, the form that enables mutagenesis |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
UmuD2 undergoes autodigestion at elevated pH |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
enzyme UmuD does not bind DNA. the enzyme UmuD interacts with several components of DNA polymerase III, including the polymerase subunit alpha, the beta clamp and the proofreading subunit epsilon, homology modeling and protein-protein docking analysis, overview. It interacts with the alpha subunit of DNA polymerase III at two distinct binding sites, one of which is adjacent to the single-stranded DNA-binding site. Enzyme UmuD specifically inhibits binding of DNA polymerase III alpha to ssDNA, UmuD residues D91 and G92 are involved in this interaction, molecular modeling, overview |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | more |
enzyme UmuD does not bind DNA |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | UmuD + H2O |
UmuD undergoes cleavage upon interaction with a RecA/ssDNA complex |
Escherichia coli |
? |
- |
? |
| 3.4.21.B30 | UmuD + H2O |
auto-cleavage of UmuD to UmuD' |
Escherichia coli |
UmuD' + ? |
- |
? |
| 3.4.21.B30 | UmuD2 + H2O |
autocleavage removes the N-terminal 24 amino acids of each UmuD2 to the remaining fragment UmuD2' |
Escherichia coli |
UmuD2' + ? |
- |
? |
| 3.4.21.B30 | UmuD2 + H2O |
slow auto-cleavage of UmuD2 to UmuD'2 |
Escherichia coli |
UmuD2' + ? |
- |
? |
| 3.4.21.B30 | UmuD2 + H2O |
slow auto-cleavage of UmuD2 to UmuD'2. The wild-type UmuD homodimer cleaves in both cis and trans conformations |
Escherichia coli |
UmuD2' + ? |
- |
? |
| 3.4.21.B30 | UmuD2 + H2O |
slow auto-cleavage of UmuD2 to UmuD'2 |
Escherichia coli AB1157 |
UmuD2' + ? |
- |
? |
