EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.18.1 | more |
cathepsin X interacts with the membrane lectin endoplasmic reticulum Golgi intermediate compartment protein-53, ERGIC-53 |
Homo sapiens |
? |
- |
? |
| 3.4.18.1 | more |
direct interaction between the enzyme and integrin alphavbeta3, overview |
Homo sapiens |
? |
- |
? |
| 3.4.18.1 | more |
luminal protein-protein interactions between components of the cargo system in the endoplasmic reticulum for secretion of cargo proteins, e.g. cathepsin C or cathepsin Z, involve the cargo transport receptor ERGIC-53, i.e. endoplasmic reticulum-Golgi intermediate compartment protein of 53 kDa, with its luminal interaction partner MCFD2, i.e. multiple coagulation factor deficiency protein 2, inactivation of ERGIC-53s lectin domain by the N156A point mutation selectively decreases the interaction of ERGIC-53 with its cargo proteins cathepsin Z and cathepsin C, whereas the N156A mutation does not affect ERGIC-53 oligomerization or its interaction with MCFD2, overview |
Homo sapiens |
? |
- |
? |
| 3.4.18.1 | more |
CATX is an important player in the spinal mechanisms involved in chronic pain induction and maintenance |
Rattus norvegicus |
? |
- |
? |
| 3.4.18.1 | more |
CATX is widely expressed in the brain and is implicated in several neurological conditions such as Alzheimer's disease, amyotrophic lateral sclerosis and age-related inflammation |
Rattus norvegicus |
? |
- |
? |
| 3.4.18.1 | more |
cathepsin X acts as a monocarboxypepidase and has a strict positional and narrower substrate specificity relative to the other human cathepsins |
Homo sapiens |
? |
- |
? |
| 3.4.18.1 | more |
cathepsin X is an important regulator of LFA-1 activity, and cathepsin X-upregulated Jurkat T cells exhibit increased homotypic aggregation, cathepsin X induces polarized migration-associated morphology in Jurkat T cells, overview |
Homo sapiens |
? |
- |
? |
| 3.4.18.1 | more |
co-localization of alpha or gamma enolase and cathepsin X. Cathepsin X impairs survival and neuritogenesis of neuronal cells, e.g. it reduces PC12 cell survival and neuritogenesis |
Homo sapiens |
? |
- |
? |
| 3.4.18.1 | more |
in addition, enzyme shows cysteine endopeptidase activity degrading gelatin, IgG and type I collagen |
Fasciola gigantica |
? |
- |
? |
| 3.4.18.1 | ortho-aminobenzoyl-Arg-Arg-(2,3-diaminopropionyl)-(2,4-dinitrophenyl)-Pro + H2O |
- |
Homo sapiens |
? |
- |
? |
