EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    3.1.2.22 | 5-bromo-4-chloro-3-indol-6-S-palmitoyl-6-thio-beta-D-glucoside + H2O |
- |
Mus musculus |
palmitate + 5-bromo-4-chloro-3-indol-6-thio-beta-D-glucoside |
- |
? |
| 3.1.2.22 | more |
enzyme assay development |
Homo sapiens |
? |
- |
? |
| 3.1.2.22 | more |
structural differences in the 2 enzyme fomrs PPT1 and PPT2, PPT2 does not hydrolyze substrates with bulky head groups |
Homo sapiens |
? |
- |
? |
| 3.1.2.22 | more |
no effect on palmitoylation of endothelial nitric oxide synthase |
Bos taurus |
? |
- |
? |
| 3.1.2.22 | more |
mutations in the enzyme protein cause the neurodegenerative disorder infantile neuronal ceroid lipofuscinosis |
Homo sapiens |
? |
- |
? |
| 3.1.2.22 | more |
defect in the palmitoyl-(protein) hydrolase gene causes a neurodegenerative disorder. Depalmitoylation of the still uncharacterized substrate(s) of the enzyme is critical for postnatal development or maintainance of cortical neurons |
Homo sapiens |
? |
- |
? |
| 3.1.2.22 | more |
the enzyme is required for the efficient lysosomal degradation of thioesters derived from S-acylated proteins |
Homo sapiens |
? |
- |
? |
| 3.1.2.22 | more |
enzyme deficiency causes infantile neuronal ceroid lipofuscinosis, the enzyme plays an important role in the development of the CNS |
Rattus norvegicus |
? |
- |
? |
| 3.1.2.22 | more |
enzyme deficiency causes progressive neurological and granular osmiophilic deposits, GROD, and infantile neuronal ceroid lipofuscinosis |
Homo sapiens |
? |
- |
? |
| 3.1.2.22 | more |
enzyme deficiency causes progressive neurological disorder infantile neuronal ceroid lipofuscinosis, INCL |
Homo sapiens |
? |
- |
? |
