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EC Number	Substrates	Commentary Substrates	Organism	Products	Commentary (Products)	Reversibility
2.1.1.59	S-adenosyl-L-methionine + cytochrome c L-lysine	overview: substrate activity of various cytochromes c	Triticum aestivum	S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine	-	?
2.1.1.59	S-adenosyl-L-methionine + cytochrome c L-lysine	overview: substrate activity of various cytochromes c	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine	a single lysine residue at position 72 of horse heart cytochrome c is methylated	?
2.1.1.59	S-adenosyl-L-methionine + cytochrome c L-lysine	overview: substrate activity of various cytochromes c	Neurospora crassa	S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine	a single lysine residue at position 72 of horse heart cytochrome c is methylated	?
2.1.1.59	S-adenosyl-L-methionine + cytochrome c L-lysine	overview: substrate activity of various cytochromes c	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine	9:17:74	?
2.1.1.59	S-adenosyl-L-methionine + cytochrome c L-lysine	overview: substrate activity of various cytochromes c	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine	mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4	?
2.1.1.59	S-adenosyl-L-methionine + cytochrome c L-lysine	overview: substrate activity of various cytochromes c	Neurospora crassa	S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine	mixture of epsilon-N-monomethyllysine, epsilon-N-dimethyllysine and epsilon-N-trimethyllysine in the ratio 1:3:4	?
2.1.1.59	S-adenosyl-L-methionine + cytochrome c L-lysine	in vivo methylation of cytochrome c in yeast occurs probably before cytochrome c is attached to the mitochondria	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine	-	?
2.1.1.59	S-adenosyl-L-methionine + cytochrome c L-lysine	regulation of enzyme and cytochrome c substrate is not in parallel manner	Saccharomyces cerevisiae	S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine	-	?
2.1.1.59	S-adenosyl-L-methionine + myoglobin L-lysine	10% activity compared to cytochrome c	Neurospora crassa	S-adenosyl-L-homocysteine + myoglobin N6-methyl-L-lysine	-	?
2.1.1.59	S-adenosyl-L-methionine + [apocytochrome c]-L-lysine	-	Triticum aestivum	S-adenosyl-L-homocysteine + [apocytochrome c]-N6-methyl-L-lysine	-	r

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Release 2023.1 (January 2023)