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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA Gram-positive 23S rRNAs are methylated at G748. 23S rRNA of Gram-negatives is methylated at G745. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate Micromonospora griseorubida S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA Gram-positive 23S rRNAs are methylated at G748. 23S rRNA of Gram-negatives is methylated at G745. The position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate Streptomyces fradiae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA the methyltransferase RlmAII (TlrB) confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae. The resistance conferred by RlmAII is highly specific for tylosin, and no resistance is conferred to other macrolide drugs, or to lincosamide and streptogramin B drugs that bind to the same region on the bacterial ribosome Streptomyces fradiae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA progressive truncation of the rRNA substrate indicates that multiple contacts occur between RlmAII and nucleotides in stem–loops 33, 34 and 35. RlmAII appears to recognize its rRNA target through specific surface shape complementarity at the junction formed by these three helices Streptococcus pneumoniae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA purified recombinant TlrB modifies G748 in 23S rRNA as well as in a 74 nucleotide RNA containing helix 35 and surrounding structures Streptomyces fradiae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA RlmAII makes multiple footprint contacts with nucleotides in stem–loops 33, 34 and 35, and does not interact elsewhere in the rRNA. Binding of RlmAII to the rRNA is dependent on the cofactor S-adenosylmethionine (or S-adenosylhomocysteine). RlmAII interacts with the same rRNA region as the orthologous enzyme RlmAI that methylates at nucleotide G745 Streptococcus pneumoniae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA the enzyme methylates 23S rRNA at nucleotide G748, which is situated in a stem-loop (hairpin 35) at the macrolide binding site of the ribosome. Binding of RlmAII methyltransferase induces chemical shift changes in the RNA. The conformation of hairpin 35 that interacts with RlmAII is radically different from the structure this hairpin adopts within the 50S subunit Streptococcus pneumoniae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA the methylation site of RlmAII is identified by liquid chromatography/electrospray ionization mass spectrometry as the N-1 position of 23S rRNA nucleotide G748 Streptomyces fradiae S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA - Streptococcus pneumoniae S1 S-adenosyl-L-homocysteine + N1-methylguanine748 in 23S rRNA - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.188S-adenosyl-L-methionine + guanine748 in 23S rRNA in vivo TlrB modifies nucleotide G748 within helix 35 of 23S rRNA Streptomyces fradiae S-adenosyl-L-homocysteine + N1-methyluanine748 in 23S rRNA - ?
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