EC Number |
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Reference |
---|
2.1.1.17 | -999 |
- |
- |
485165, 485175, 485176 |
2.1.1.17 | -999 |
- |
phosphatidylethanolamine N-methyltransferase activity is significantly lower in Mdr2 (+/-) compared to Mdr2 (+/+) mice: 1.20 nmol/mg/min vs. 1.98 nmol/mg/min. After 7 days on methionine and choline deficient diet enzyme activity is: Mdr2 (+/-) = 1.31 nmol/mg/min vs. Mdr2 (+/+) = 1.96 nmol/mg/min. After 30 days on methionine and choline deficient diet enzyme activity is: Mdr2 (+/-) = 1.60 nmol/mg/min vs. Mdr2 (+/+) = 1.99 nmol/mg/min |
675181 |
2.1.1.17 | -999 |
- |
the activity of phosphatidylethanolamine N-methyltransferase increases (58% higher on day 5, 72% higher on day 7) over 7 d following the injection of streptozotocin (injection of 60 mg/kg on day 0). Diabetes increases the phosphatidylethanolamine N-methyltransferase activity and abundance. Administration of all-trans-retinoic acid alone or in combination with streptozotocin has no effect on phosphatidylethanolamine N-methyltransferase activity. Phosphatidylethanolamine N-methyltransferase activity and abundance in the streptozotocin + insulin group is not significantly different from control values. The enzymatic activity of phosphatidylethanolamine N-methyltransferase is determined by measuring the incorporation of radiolabled methyl groups from S-adenosyl-L-[methyl-3H]methionine into phospholipids. |
675568 |
2.1.1.17 | -999 |
- |
there is a significant positive linear relationship between phosphatidylethanolamine N-methyltransferase activity and S-adenosylmethionine:S-adenosylhomocysteine ratio (r = 0.45). There is a significant inverse relationship between phosphatidylethanolamine N-methyltransferase activity and triglycerids. The metabolic conversion of radiolabeled phosphatidylethanolamine to phosphatidylcholine over 3 h incubation period is taken as a measure of phosphatidylethanolamine N-methyltransferase. |
675185 |
2.1.1.17 | 0.273 |
- |
- |
485167 |
2.1.1.17 | 0.63 |
- |
activity with phosphatidylethanolamine |
485164 |
2.1.1.17 | 3.75 |
- |
activity with phosphatidyl-N-monomethylethanolamine |
485164 |
2.1.1.17 | 8.59 |
- |
activity with phosphatidyl-N,N-dimethyl-ethanolamine |
485164 |