EC Number |
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Reference |
---|
1.3.1.48 | -999 |
- |
after restoration of LTBDH/PGR expression in LTBDH/PGR-negative (H1299) or -low (A549) lung cancer cell lines, the restored enzyme induces apoptosis and growth inhibition in vitro, restoration of LTBDH/PGR expression is effective in preventing lung cancer growth in vitro and in vivo |
699958 |
1.3.1.48 | -999 |
- |
cell cycle alterations induced by LTBDH/PGR over-expression are assessed with Ad-GFP or Ad-PGR after infection at 100 MOI for 72 h, after infection with Ad-PGR, the apoptosis population in A549 cells and H1299 cells is 8.59% and 9.57%, whereas apoptosis population is not detected significantly in H157 infected cells |
699958 |
1.3.1.48 | -999 |
- |
effects of induced expression of LTBDH/PGR in H1299 cells, LTBDH/PGR expression increases in a dose and time dependent manner after tetracycline treatment, marked expression is observed at day 4 and significantly affects cell proliferation beginning day 5 causing reduction in cell number and suggesting that LTBDH/PGR expression inhibit growth of H1299 cells |
699958 |
1.3.1.48 | -999 |
- |
the expression of apoptosis-related proteins BAX, Bcl-2 and CD44 in H1299 and H157 cells is not changed by LTBDH/PGR over-expression except for BAX which is decreased in H157 cells, endogenous p53 and p21 are not expressed in both H1299 and H157 cells |
699958 |
1.3.1.48 | 0.00026 |
- |
enzyme activity in cornea, substrate 15-ketoprostaglandin, cofactor NADPH |
390825 |
1.3.1.48 | 0.000389 |
- |
enzyme activity in retina, substrate 15-ketoprostaglandin, cofactor NADPH |
390825 |
1.3.1.48 | 0.00085 |
- |
enzyme activity in retinal pigment epithelium, substrate 15-ketoprostaglandin, cofactor NADPH |
390825 |
1.3.1.48 | 0.000945 |
- |
enzyme purified from iris-ciliary cytosol |
390825 |
1.3.1.48 | 0.0012 |
- |
enzyme activity in ciliary body, substrate 15-ketoprostaglandin, cofactor NADPH |
390825 |
1.3.1.48 | 0.00145 |
- |
enzyme activity in iris, substrate 15-ketoprostaglandin, cofactor NADPH |
390825 |