EC Number   |
Source Tissue |
Reference |
|---|
   2.1.1.77 | A-549 cell |
- |
756674 |
| 2.1.1.77 | anaplastic astrocytoma cell |
69% reduced PIMT expression as compared to normal brains |
659913 |
| 2.1.1.77 | aortic endothelium |
PIMT expression in bovine aortic endothelial cells is regulated by cell detachment and readhesion to a substratum |
671815 |
| 2.1.1.77 | astrocytoma cell |
enzyme expression and enzyme activity are significantly decreased in all grades of tumors, 76% reduced PIMT expression in pilocytic astrocytomas (grade I), 46% reduced PIMT expression in astrocytomas (grade II), 69% reduced PIMT expression in anaplastic astrocytomas (grade III) |
659913 |
| 2.1.1.77 | astrocytoma cell |
enzyme expression and enzyme activity are significantly decreased in all grades of tumors, 76% reduced PIMT expression in pilocytic astrocytomas (grade I), 46% reduced PIMT expression in astrocytomas (grade II), 69% reduced PIMT expression in anaplastic astrocytomas (grade III), 80% reduced PIMT expression in glioblastomas (grade IV) as compared to normal brains |
659913 |
| 2.1.1.77 | astrocytoma cell line |
treatment of astrocytoma cells (U-87) with direct pharmacological GSK-3 inhibitors stimulate PIMT expression (2fold). Results demonstrate regulation of PIMT expression by GSK-3 inhibitor lithium at both the transcriptional and the translational levels. Inhibition by siRNA of GSK-3 and beta-catenin modulates expression of the PIMT in accordance with GSK-3 pharmacological inhibition. Valproic acid up-regulates phospho-GSK-3b (Ser9), beta-catenin and PIMT levels similarly to lithium |
689203 |
| 2.1.1.77 | blood |
- |
-, 485594, 485595, 485605, 485609, 485613, 485615, 703773 |
| 2.1.1.77 | body wall |
- |
705487 |
| 2.1.1.77 | brain |
- |
-, 485591, 485592, 485593, 485594, 485595, 485596, 485597, 485598, 485600, 485605, 485606, 485611, 485612, 485613, 485614, 485615, 485617, 659913, 735062 |
| 2.1.1.77 | carcinoma cell |
PIMT levels are regulated by cell adhesion in various cancer cell lines. The upregulation of PIMT expression could be prevented by an anti-alphavbeta3 antibody (LM609) or by a cyclic RGD peptide (XJ735) specific to integrin alphavbeta3. PIMT expression returns to the basal level when cells are replated on a substratum after detachment, though downregulation of PIMT expression could be partly prevented by the PI3K inhibitors LY294002 and wortmannin, as well as by the proteasome inhibitors MG-132, lactacystin, and beta-lactone |
671815 |
