EC Number |
Source Tissue |
Reference |
---|
1.1.1.141 | A-427 cell |
- |
689069 |
1.1.1.141 | A-549 cell |
- |
668172, 685958, 689069, 695883, 740148, 740159 |
1.1.1.141 | A-549 cell |
lung adenocarcinoma cell line |
667558, 668173 |
1.1.1.141 | A-549 cell |
up-regulation of cyclooxygenase-2 expression by pro-inflammatory cytokines is accompanied by down-regluation of 15-hydroxyprostaglandin dehydrogenase expression. Over-expression of cyclooxygenase-2 but not -1 also attenuates 15-hydroxyprostaglandin dehydrogenase expression. Similarly, overexpression of 15-hydroxyprostaglandin dehydrogenase inhibits interleukin 1beta-induced cyclooxygenase-2 expression and results in apoptosis. The levels of 15-hydroxyprostaglandin dehydrogenase expression in transfected cells correlate positively with those of mesenchymal markers, and negatively with those of epithelial markers |
689843 |
1.1.1.141 | adenocarcinoma cell line |
non-small cell lung carcinoma cell line A549, expression of 15-PGDH is induced by dexamethason, prednisolone, betamethasone and triamcinolone |
654380 |
1.1.1.141 | adrenal cortex |
both 15-hydroxyprostaglandin dehydrogenase mRNA and protein levels are significantly higher in kidney cortex than in papilla. Enzyme is mainly localized to the tubular epithelial cells in kidney cortex and outer medulla |
684372 |
1.1.1.141 | amnion |
55000 Da form of enzyme, level increases with preterm premature rupture of membrane |
690004 |
1.1.1.141 | aorta |
- |
741244 |
1.1.1.141 | bladder |
- |
669380 |
1.1.1.141 | brain |
- |
285912, 285930, 699476 |