EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.141 | 15-hydroxyprostaglandin dehydrogenase (NAD+) |
keratinocyte |
in hair follicle, 15-hydroxyprostaglandin dehydrogenase is expressed mainly in keratinocytes and melanocytes |
686593 |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase |
keratinocyte |
- |
739986, 760685, 762406 |
1.1.1.34 | hydroxymethylglutaryl-CoA reductase (NADPH) |
keratinocyte |
- |
-, 687713 |
1.1.1.34 | hydroxymethylglutaryl-CoA reductase (NADPH) |
keratinocyte |
NCTC 2544 cells. HMG-CoA reductase and peroxisome proliferator-activated receptor alpha are involved in clofibrate-induced apoptosis in human keratinocytes |
667236 |
1.11.1.8 | iodide peroxidase |
keratinocyte |
- |
712669 |
1.13.11.20 | cysteine dioxygenase |
keratinocyte |
- |
725864 |
1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase |
keratinocyte |
- |
395394 |
1.13.11.31 | arachidonate 12-lipoxygenase |
keratinocyte |
- |
703699 |
1.13.11.31 | arachidonate 12-lipoxygenase |
keratinocyte |
platelet-type enzyme is the 12-lipoxygenase isoform responsible for the generation of most of the 12-hydroxyeicosateteaenoic acid |
395426 |
1.13.11.33 | arachidonate 15-lipoxygenase |
keratinocyte |
- |
673030, 677239, 703699 |
1.13.11.33 | arachidonate 15-lipoxygenase |
keratinocyte |
neonatal foreskin cultured keratinocytes |
639249 |
1.13.11.34 | arachidonate 5-lipoxygenase |
keratinocyte |
normal skin keratinocytes and a cell line of human keratinocytes, HaCaT |
439469 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
keratinocyte |
of skin squamous epithelium |
728342 |
1.14.11.68 | [histone H3]-trimethyl-L-lysine27 demethylase |
keratinocyte |
- |
745509 |
1.14.11.69 | [histone H3]-trimethyl-L-lysine36 demethylase |
keratinocyte |
foreskin kearinocyte |
755216 |
1.14.13.8 | flavin-containing monooxygenase |
keratinocyte |
- |
675600 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
keratinocyte |
- |
689252 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
keratinocyte |
epidermal |
687555 |
1.14.15.16 | vitamin D3 24-hydroxylase |
keratinocyte |
- |
714302 |
1.14.15.16 | vitamin D3 24-hydroxylase |
keratinocyte |
neonatal foreskin keratinocyte |
713944 |
1.14.16.2 | tyrosine 3-monooxygenase |
keratinocyte |
undifferentiated, hydroxylase isoenzyme I mRNA, no detection of isoenzyme 2, 3 and 4 |
658660 |
1.14.16.4 | tryptophan 5-monooxygenase |
keratinocyte |
- |
658187 |
1.14.18.6 | 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase |
keratinocyte |
FA2H is expressed in cultured human keratinocytes and human epidermis, with FA2H expression and fatty acid 2-hydroxylase activity increasing with differentiation |
734156 |
1.14.18.9 | 4alpha-methylsterol monooxygenase |
keratinocyte |
epidermal |
727093 |
1.14.18.B1 | 5,6-dihydroxyindole-2-carboxylic acid oxidase |
keratinocyte |
epidermal keratinocytes |
745509 |
1.14.19.20 | DELTA7-sterol 5(6)-desaturase |
keratinocyte |
- |
-, 745646 |
1.17.3.2 | xanthine oxidase |
keratinocyte |
- |
686881 |
1.17.4.1 | ribonucleoside-diphosphate reductase |
keratinocyte |
- |
657780 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
keratinocyte |
- |
691603 |
1.2.1.5 | aldehyde dehydrogenase [NAD(P)+] |
keratinocyte |
- |
711110 |
1.2.4.1 | pyruvate dehydrogenase (acetyl-transferring) |
keratinocyte |
- |
741340 |
1.21.99.4 | thyroxine 5'-deiodinase |
keratinocyte |
thyronine 5'-deiodinase type II |
639409 |
1.3.1.21 | 7-dehydrocholesterol reductase |
keratinocyte |
- |
740913 |
1.3.1.24 | biliverdin reductase |
keratinocyte |
- |
711662 |
1.3.5.2 | dihydroorotate dehydrogenase (quinone) |
keratinocyte |
- |
712071 |
1.3.99.5 | 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor) |
keratinocyte |
epidermal and follicular |
713519 |
1.4.3.13 | protein-lysine 6-oxidase |
keratinocyte |
LOX and LOXL, of skin epidermis and hair follicles |
659751 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
keratinocyte |
- |
686880 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
keratinocyte |
up-regulation of enzyme upon exposure to L-dopa and tetrahydropapaveroline |
674023 |
1.8.1.9 | thioredoxin-disulfide reductase |
keratinocyte |
- |
394908, 394917, 675760, 711672 |
1.8.4.11 | peptide-methionine (S)-S-oxide reductase |
keratinocyte |
chronic sun exposure of human epidermis and high dose UVA irradiation of cultured human keratinocytes results in a decline of MsrA expression and/or Msr activity |
686598 |
2.1.1.320 | type II protein arginine methyltransferase |
keratinocyte |
- |
756415 |
2.3.1.135 | phosphatidylcholine-retinol O-acyltransferase |
keratinocyte |
- |
715720 |
2.3.1.24 | sphingosine N-acyltransferase |
keratinocyte |
epidermal, expression analysis of the CerS family members during keratinocyte differentiation, overview |
754361 |
2.3.1.296 | omega-hydroxyceramide transacylase |
keratinocyte |
- |
752823, 753772, 754365, 754841 |
2.3.1.297 | very-long-chain ceramide synthase |
keratinocyte |
- |
757470 |
2.3.1.297 | very-long-chain ceramide synthase |
keratinocyte |
epidermal, expression analysis of the CerS family members during keratinocyte differentiation, overview. A slight increase in CerS4 mRNA is observed at the late stage of differentiation |
754361 |
2.3.1.297 | very-long-chain ceramide synthase |
keratinocyte |
epidermal, expression analysis of the CerS family members during keratinocyte differentiation, overview. Expression of CerS2 mRNA remains nearly unchanged during differentiation |
754361 |
2.3.1.298 | ultra-long-chain ceramide synthase |
keratinocyte |
- |
753770, 754361, 755196 |
2.3.1.298 | ultra-long-chain ceramide synthase |
keratinocyte |
epidermal, expression analysis of the CerS family members during keratinocyte differentiation, overview. Upon differentiation, CerS3 mRNA expression significantly increases and remains high throughout differentiation |
754361 |
2.3.1.299 | sphingoid base N-stearoyltransferase |
keratinocyte |
- |
754361 |
2.3.1.50 | serine C-palmitoyltransferase |
keratinocyte |
- |
487174 |
2.3.1.50 | serine C-palmitoyltransferase |
keratinocyte |
neonatal |
487159 |
2.3.1.57 | diamine N-acetyltransferase |
keratinocyte |
- |
662583 |
2.3.1.76 | retinol O-fatty-acyltransferase |
keratinocyte |
D033 line |
487496 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
keratinocyte |
epidermal |
729520 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
keratinocyte |
- |
736069, 759166 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
keratinocyte |
neonate keratinoycte cell culture |
758724 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
keratinocyte |
transglutaminase 5 |
487875 |
2.4.1.122 | N-acetylgalactosaminide beta-1,3-galactosyltransferase |
keratinocyte |
- |
723563 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
keratinocyte |
- |
722199 |
2.4.1.17 | glucuronosyltransferase |
keratinocyte |
- |
735649 |
2.4.1.212 | hyaluronan synthase |
keratinocyte |
- |
395260, 693592, 722816, 736064, 736219 |
2.4.1.212 | hyaluronan synthase |
keratinocyte |
epidermal keratinocyte |
690807 |
2.4.1.212 | hyaluronan synthase |
keratinocyte |
epidermal keratinocyte, NHEK(F) cell |
690619 |
2.4.1.221 | peptide-O-fucosyltransferase |
keratinocyte |
- |
736272 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
keratinocyte |
- |
686257 |
2.4.1.66 | procollagen glucosyltransferase |
keratinocyte |
- |
737090 |
2.4.1.80 | ceramide glucosyltransferase |
keratinocyte |
- |
489418, 489420, 489421 |
2.6.1.13 | ornithine aminotransferase |
keratinocyte |
- |
758876 |
2.7.1.137 | phosphatidylinositol 3-kinase |
keratinocyte |
- |
708568 |
2.7.1.138 | ceramide kinase |
keratinocyte |
mouse keratinocyte cell line SP1 |
692307 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
keratinocyte |
- |
708568 |
2.7.1.36 | mevalonate kinase |
keratinocyte |
- |
759158 |
2.7.1.68 | 1-phosphatidylinositol-4-phosphate 5-kinase |
keratinocyte |
- |
675959 |
2.7.10.1 | receptor protein-tyrosine kinase |
keratinocyte |
- |
490543, 490580, 672964 |
2.7.10.1 | receptor protein-tyrosine kinase |
keratinocyte |
foreskin |
690303 |
2.7.10.1 | receptor protein-tyrosine kinase |
keratinocyte |
foreskin keratinocytes |
490562 |
2.7.10.2 | non-specific protein-tyrosine kinase |
keratinocyte |
- |
490632 |
2.7.10.2 | non-specific protein-tyrosine kinase |
keratinocyte |
Srm, Src, Fyn, Yes |
660885 |
2.7.11.1 | non-specific serine/threonine protein kinase |
keratinocyte |
- |
662053 |
2.7.11.1 | non-specific serine/threonine protein kinase |
keratinocyte |
isozyme PRK2/PKNgamma/PAK-2 |
662053 |
2.7.11.10 | IkappaB kinase |
keratinocyte |
epidermal |
662516 |
2.7.11.22 | cyclin-dependent kinase |
keratinocyte |
- |
664536 |
2.7.11.24 | mitogen-activated protein kinase |
keratinocyte |
- |
663830, 740938 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
keratinocyte |
- |
681023, 682213 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
keratinocyte |
DLK acts as a key regulator of keratinocyte terminal differentiation and cornification |
665606 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
keratinocyte |
- |
693151 |
2.7.4.2 | phosphomevalonate kinase |
keratinocyte |
- |
760138 |
2.7.4.6 | nucleoside-diphosphate kinase |
keratinocyte |
- |
723631 |
2.7.7.49 | RNA-directed DNA polymerase |
keratinocyte |
- |
693914 |
2.8.2.15 | steroid sulfotransferase |
keratinocyte |
- |
738102 |
2.8.2.15 | steroid sulfotransferase |
keratinocyte |
epidermal, primary cultures |
662582 |
2.8.2.4 | estrone sulfotransferase |
keratinocyte |
epidermal |
677219 |
3.1.1.4 | phospholipase A2 |
keratinocyte |
sPLA2-IIF is expressed in terminally differentiated keratinocytes in the suprabasal epidermis and markedly increased in psoriatic skin |
751474 |
3.1.1.47 | 1-alkyl-2-acetylglycerophosphocholine esterase |
keratinocyte |
epidermal, isozyme II, lower amount compared to sebaceous gland |
652697 |
3.1.3.16 | protein-serine/threonine phosphatase |
keratinocyte |
- |
709404 |
3.1.3.16 | protein-serine/threonine phosphatase |
keratinocyte |
epidermal |
708177 |
3.1.3.3 | phosphoserine phosphatase |
keratinocyte |
- |
715741 |
3.1.3.48 | protein-tyrosine-phosphatase |
keratinocyte |
- |
665690 |