EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
hypothalamus |
in females, the level is the highest in the hypothalamus |
740503 |
1.1.1.145 | 3beta-hydroxy-DELTA5-steroid dehydrogenase |
hypothalamus |
in males, the highest transcript level is in telencephalon and hypothalamus |
740503 |
1.1.1.153 | sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) |
hypothalamus |
neurons |
655138 |
1.1.1.178 | 3-hydroxy-2-methylbutyryl-CoA dehydrogenase |
hypothalamus |
- |
673530 |
1.1.1.270 | 3beta-hydroxysteroid 3-dehydrogenase |
hypothalamus |
- |
286475 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
hypothalamus |
- |
389558, 389561, 656642 |
1.1.1.50 | 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) |
hypothalamus |
cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductase activity |
389559 |
1.11.1.24 | thioredoxin-dependent peroxiredoxin |
hypothalamus |
0.0013 mg Prx I per mg of soluble protein Prx I, 0.0013 mg Prx II per mg of soluble protein, 0.0005 mg Prx III per mg of soluble protein, 0.0007 mg Prx V per mg of soluble protein and 0.0007 mg Prx VI per mg of soluble protein |
655756 |
1.13.11.34 | arachidonate 5-lipoxygenase |
hypothalamus |
- |
439477 |
1.13.11.71 | carotenoid-9',10'-cleaving dioxygenase |
hypothalamus |
- |
745596 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
hypothalamus |
- |
440224, 697042 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
hypothalamus |
estradiol regulates the nitrergic system in the supraoptic and paraventricular hypothalamic nuclei under acute osmotic stress conditions, but the effects specifically depend on the anatomical subregions and different estrogen receptors |
743360 |
1.14.13.39 | nitric-oxide synthase (NADPH) |
hypothalamus |
neurons of several nuclei of the hypothalamus, such as the arcuate nucleus (ARC) and paraventricular nucleus (PVN) |
-, 763849 |
1.14.14.14 | aromatase |
hypothalamus |
AROM and NOS proteins are coexpressed with NADPH oxidase in the preoptic-anterior hypothalamus |
764772 |
1.14.14.14 | aromatase |
hypothalamus |
in the female, activity is detecable throughout the year |
745062 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
hypothalamus |
immortalized hypothalamic neurons GT1-7 |
689226 |
1.14.14.19 | steroid 17alpha-monooxygenase |
hypothalamus |
- |
715984, 727367 |
1.14.15.18 | calcidiol 1-monooxygenase |
hypothalamus |
high enzyme level |
659563 |
1.14.15.4 | steroid 11beta-monooxygenase |
hypothalamus |
- |
688009 |
1.14.16.2 | tyrosine 3-monooxygenase |
hypothalamus |
- |
658785, 659762, 673820, 687935, 745402 |
1.14.16.2 | tyrosine 3-monooxygenase |
hypothalamus |
2fold activity under cold stress. Injection of the angiotensin converting enzyme inhibitor enalapril malate prevented the increase of tyrosine hydroxylase under cold stress |
672960 |
1.14.16.2 | tyrosine 3-monooxygenase |
hypothalamus |
anterior and posterior |
684367 |
1.14.16.2 | tyrosine 3-monooxygenase |
hypothalamus |
in some cells of the hypothalamus, tyrosine hydroxylase is colocalized with vasoactive intestinal peptide |
695603 |
1.14.16.2 | tyrosine 3-monooxygenase |
hypothalamus |
posterior |
689999 |
1.14.16.2 | tyrosine 3-monooxygenase |
hypothalamus |
the enzyme content is reduced in the hypothalamic paraventricular nucleus, neurons and neuropil, of the seizure-sensitive gerbils |
688723 |
1.14.16.4 | tryptophan 5-monooxygenase |
hypothalamus |
- |
-, 687220, 689087, 727949 |
1.14.17.1 | dopamine beta-monooxygenase |
hypothalamus |
- |
438636, 727633, 744598 |
1.14.17.3 | peptidylglycine monooxygenase |
hypothalamus |
- |
438565, 697630 |
1.14.17.3 | peptidylglycine monooxygenase |
hypothalamus |
2 forms, distinguishable by molecular weight |
438582 |
1.14.17.3 | peptidylglycine monooxygenase |
hypothalamus |
PAM-1 and PAM-2 |
438587 |
1.14.99.1 | prostaglandin-endoperoxide synthase |
hypothalamus |
fetal |
686417 |
1.15.1.1 | superoxide dismutase |
hypothalamus |
TCAP-1-responsive, immortalized N38 cells |
685881 |
1.2.4.4 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) |
hypothalamus |
- |
725082 |
1.21.99.4 | thyroxine 5'-deiodinase |
hypothalamus |
- |
697632 |
1.3.1.22 | 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) |
hypothalamus |
- |
389558, 389559, 389561, 390653, 390659, 390662 |
1.4.3.1 | D-aspartate oxidase |
hypothalamus |
- |
743140 |
1.4.3.1 | D-aspartate oxidase |
hypothalamus |
in the cell bodies of the neurons |
711719 |
1.4.3.3 | D-amino-acid oxidase |
hypothalamus |
- |
699164 |
1.4.3.4 | monoamine oxidase |
hypothalamus |
MAO expression and activity are located in or adjacent to serotonergic nuclei and their targets especially in the ventral hypothalamus |
-, 705252 |
1.8.3.2 | thiol oxidase |
hypothalamus |
high expression in neurons producing disulfide-bounded neuropeptides |
659578 |
2.1.1.6 | catechol O-methyltransferase |
hypothalamus |
- |
685455 |
2.1.1.96 | thioether S-methyltransferase |
hypothalamus |
- |
676338 |
2.3.1.23 | 1-acylglycerophosphocholine O-acyltransferase |
hypothalamus |
- |
755989 |
2.3.1.6 | choline O-acetyltransferase |
hypothalamus |
afferent varicose fibers are immunopositive for ChAT in the ventral telencephalon, the preoptic area, the hypothalamus and the posterior tuberculum |
756641 |
2.3.1.85 | fatty-acid synthase system |
hypothalamus |
- |
661661 |
2.3.2.5 | glutaminyl-peptide cyclotransferase |
hypothalamus |
- |
487990, 704085, 735738, 759702 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
hypothalamus |
- |
-, 736174 |
2.4.3.8 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase |
hypothalamus |
- |
-, 736174, 764907 |
2.4.3.9 | lactosylceramide alpha-2,3-sialyltransferase |
hypothalamus |
- |
-, 736174 |
2.5.1.16 | spermidine synthase |
hypothalamus |
highest levels of expression in nucleus accumbens, taenia tecta, cerebellar cortex, cerebral cortical layer I, hippocampus, hypothalamus, mesencephalic raphe nuclei, central and lateral amygdala, and the circumventricular organs |
688510 |
2.6.1.19 | 4-aminobutyrate-2-oxoglutarate transaminase |
hypothalamus |
- |
672849, 675530 |
2.6.1.19 | 4-aminobutyrate-2-oxoglutarate transaminase |
hypothalamus |
enzyme activity of gamma-aminobutanoate transaminase is highest in the hypothalamus and optic textum |
672849 |
2.6.1.42 | branched-chain-amino-acid transaminase |
hypothalamus |
- |
675509 |
2.6.1.64 | glutamine-phenylpyruvate transaminase |
hypothalamus |
- |
-, 759850 |
2.7.1.1 | hexokinase |
hypothalamus |
- |
641072, 703290, 738756 |
2.7.1.1 | hexokinase |
hypothalamus |
enzyme activities increase in the ventromedial hypothalamus as the glucose concentration rises. Enzyme activities in lateral hypothalamus decreases at 2.8 mM and 20 mM glucose |
675095 |
2.7.1.1 | hexokinase |
hypothalamus |
expression is altered by feeding conditions, especially in liver and hypothalamus where food deprivation decreases and refeeding increases expression. Activity in refed fish is higher than that of fed fish |
671258 |
2.7.1.1 | hexokinase |
hypothalamus |
the hypothalamus is the region of maximum activity (17.2%) |
705268 |
2.7.1.105 | 6-phosphofructo-2-kinase |
hypothalamus |
- |
-, 738904 |
2.7.1.105 | 6-phosphofructo-2-kinase |
hypothalamus |
expressed at high abundance in both hypothalami and clonal hypothalamic neurons. In response to re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami |
723032 |
2.7.1.137 | phosphatidylinositol 3-kinase |
hypothalamus |
- |
-, 723027 |
2.7.1.151 | inositol-polyphosphate multikinase |
hypothalamus |
- |
723659 |
2.7.1.20 | adenosine kinase |
hypothalamus |
- |
661642 |
2.7.10.1 | receptor protein-tyrosine kinase |
hypothalamus |
- |
672851 |
2.7.11.1 | non-specific serine/threonine protein kinase |
hypothalamus |
- |
-, 723027 |
2.7.11.11 | cAMP-dependent protein kinase |
hypothalamus |
- |
662681 |
2.7.11.12 | cGMP-dependent protein kinase |
hypothalamus |
- |
661531 |
2.7.11.12 | cGMP-dependent protein kinase |
hypothalamus |
predominant expression of isozyme cGKIbeta |
662962 |
2.7.11.13 | protein kinase C |
hypothalamus |
- |
662681 |
2.7.11.17 | Ca2+/calmodulin-dependent protein kinase |
hypothalamus |
- |
666110 |
2.7.11.2 | [pyruvate dehydrogenase (acetyl-transferring)] kinase |
hypothalamus |
- |
761984 |
2.7.11.25 | mitogen-activated protein kinase kinase kinase |
hypothalamus |
- |
762367 |
2.7.11.27 | [acetyl-CoA carboxylase] kinase |
hypothalamus |
- |
693951, 740990 |
2.7.11.27 | [acetyl-CoA carboxylase] kinase |
hypothalamus |
determination of levels of hypothalamic phosphorylation of AMPK |
-, 741273 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
hypothalamus |
- |
692267, 692682, 705267 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
hypothalamus |
dorso-mediobasal |
705267 |
2.7.11.31 | [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase |
hypothalamus |
ventromedial hypothalamus |
692000 |
2.7.12.2 | mitogen-activated protein kinase kinase |
hypothalamus |
high expression level of MKK4 |
682214 |
2.7.12.2 | mitogen-activated protein kinase kinase |
hypothalamus |
highest levels of expression |
682214 |
3.1.1.3 | triacylglycerol lipase |
hypothalamus |
- |
709885 |
3.1.1.4 | phospholipase A2 |
hypothalamus |
- |
691482, 693770 |
3.1.1.7 | acetylcholinesterase |
hypothalamus |
- |
680122, 682110 |
3.1.3.108 | nocturnin |
hypothalamus |
almost no changes of noc-b mRNAs are observed after a meal |
755768 |
3.1.3.108 | nocturnin |
hypothalamus |
high expression |
755768 |
3.1.3.108 | nocturnin |
hypothalamus |
moderate expression |
755768 |
3.1.3.108 | nocturnin |
hypothalamus |
noc-a mRNAs rise sharply after a meal |
755768 |
3.1.3.16 | protein-serine/threonine phosphatase |
hypothalamus |
in the supraoptic nucleus and the lateral preoptic area |
655140 |
3.1.3.36 | phosphoinositide 5-phosphatase |
hypothalamus |
highly expressed in neurons of the arcuate and lateral nuclei of the hypothalamus. Treatment with a phosphorthioate-modified antisense oligonucleotide for 5ptase IV reduces the hypothalamic expression of 5ptase IV by approximately 80% |
679517 |
3.1.3.48 | protein-tyrosine-phosphatase |
hypothalamus |
- |
709938 |
3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
hypothalamus |
- |
694494 |
3.1.3.B4 | phosphatidylinositol-4-phosphate phosphatase |
hypothalamus |
high expression |
751173 |
3.1.4.1 | phosphodiesterase I |
hypothalamus |
highest enzyme activities in synaptic membranes from cerebellum, hypothalamus, hippocampus |
682106 |
3.1.4.17 | 3',5'-cyclic-nucleotide phosphodiesterase |
hypothalamus |
- |
716347 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
hypothalamus |
- |
716347 |
3.1.4.4 | phospholipase D |
hypothalamus |
immunostaining weaker than in granule cell or vomeronasal nerve |
681093 |
3.1.4.46 | glycerophosphodiester phosphodiesterase |
hypothalamus |
- |
679873 |
3.1.4.53 | 3',5'-cyclic-AMP phosphodiesterase |
hypothalamus |
- |
716347 |
3.1.4.54 | N-acetylphosphatidylethanolamine-hydrolysing phospholipase D |
hypothalamus |
ventromedial nucleus. N-arachidonoylphosphatidylethanolamine phospholipase D is localized presynaptically and postsynaptically but shows a preferential distribution in dendrites. The dorsomedial region of the ventromedial nucleus of the hypothalamus displays the necessary machinery for the endocannabinoid-mediated modulation of synaptic transmission of brain circuitries that regulate important hypothalamic functions such as feeding behaviors |
729811 |
3.3.2.10 | soluble epoxide hydrolase |
hypothalamus |
- |
661683 |
3.3.2.9 | microsomal epoxide hydrolase |
hypothalamus |
- |
663275 |