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in a murine model of absent securin expression, the PTTG knock-out mouse, separase and Rad21 are over-expressed in multiple brain regions. Furthermore, Rad21 mRNA expression is highly correlated with that of securin, separase, cyclin C and sestrin 2 in fetal brains
increased expression of separase
Separase is significantly overexpressed in human breast tumors compared with matched normal tissue (Western blot)
highly expressed in human fetal cerebral cortex compared with adult
separase expression is very high in both normal nonneoplastic and neoplastic colons
separase localizes to the ingressing furrow and midbody during cytokinesis in the Caenorhabditis elegans embryo
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