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Source Tissue
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fibroblast cell, non-dividing cells expressing enzyme subunit p53R2, but not sunit R2 protein, have reduced dNTP levels if exposed to the enzyme--specific inhibitor hydroxyurea. After DNA damage, a slow, up to 4fold increase in p53R2 expression leads to 3fold increase in dNTP pools in G0/G1 cells
significant induction of subunit R2 following blood feeding
isozymes R2 and p53R2
subunit R2 isoforms TSO2 and RNR2A
colon cancer cell. Cell line expresses subunit R2 in excess resulting in protection against DNA damage and replication stress
promyelocytic leukemia cells
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