EC Number   |
Source Tissue |
Reference |
|---|
   3.4.22.49 | cerebral cortex |
highly expressed in human fetal cerebral cortex compared with adult |
681037 |
| 3.4.22.49 | more |
human separase is present in cells as a part of very large protein complex, which in addition to securin contains also Cdk and cyclin B1, both able to inhibit separase |
718194 |
| 3.4.22.49 | brain |
in a murine model of absent securin expression, the PTTG knock-out mouse, separase and Rad21 are over-expressed in multiple brain regions. Furthermore, Rad21 mRNA expression is highly correlated with that of securin, separase, cyclin C and sestrin 2 in fetal brains |
681037 |
| 3.4.22.49 | breast cancer cell |
increased expression of separase |
697382 |
| 3.4.22.49 | osteosarcoma cell |
increased expression of separase |
697382 |
| 3.4.22.49 | prostate cancer cell line |
increased expression of separase |
697382 |
| 3.4.22.49 | bone cancer cell |
overexpressed in numerous human cancers including breast, bone, brain, and prostate |
752903 |
| 3.4.22.49 | brain cancer cell |
overexpressed in numerous human cancers including breast, bone, brain, and prostate |
752903 |
| 3.4.22.49 | breast cancer cell |
overexpressed in numerous human cancers including breast, bone, brain, and prostate |
752903 |
| 3.4.22.49 | prostate gland cancer cell |
overexpressed in numerous human cancers including breast, bone, brain, and prostate |
752903 |
