EC Number |
General Information |
Reference |
---|
7.6.2.4 | evolution |
ABCD1-3 belong to the ATP-binding cassette protein superfamily, subfamily D, membrane-bound proteins with highly conserved structure |
749821 |
7.6.2.4 | evolution |
the ABCD1 transporter belongs to the D subfamily of the ATP-binding cassette (ABC)2 transporter family and is encoded by the ABCD1 gene |
751104 |
7.6.2.4 | evolution |
the ABCD2 transporter belongs to the D subfamily of the ATP-binding cassette (ABC)2 transporter family and is encoded by the ABCD1 gene |
751104 |
7.6.2.4 | evolution |
the LLL motif likely belongs to a hydrophobic helix, which is quite well conserved in other ABCD transporters (20-23 in ABCD3). The IL motif near the TMH 5 (I307-L308) belongs to a consensus sequence composed of three hydrophobic residues |
750860 |
7.6.2.4 | evolution |
the LLL motif likely belongs to a hydrophobic helix, which is quite well conserved in other ABCD transporters (20-36 in ABCD1). The IL motif near the TMH 5 belongs to a consensus sequence composed of three hydrophobic residues [FL]-I-[FL] (LIL in ABCD1) |
750860 |
7.6.2.4 | malfunction |
germination of ped3 mutants is significantly impaired, suggesting that PED3 regulates dormancy and germination. A ped3 abi5 (ABA insensitive 5) double mutant does not show any of the expression patterns of ped3 mutants and rescues the impaired germination phenotype of the ped3 mutant. The impaired germination of ped3 can also be rescued by removal of pectin from the seed coat using exogenous polygalacturonase or acidic conditions |
713285 |
7.6.2.4 | metabolism |
the peroxisomal import of fatty acids is mediated by 3 ATP-binding cassette transporters (ABCD1, -2, and -3). Transport mediated by ABCD3 is crucial in the peroxisomal degradation of medium-chain fatty acids and might be involved in the production of CO2 and acid-soluble products from C16-carnitine. Mitochondrial FAO inhibition with etomoxir does not lead to significant accumulation of any acylcarnitine species |
750514 |
7.6.2.4 | more |
absence of interaction between solubilized ABCD1 and ABCD2 within supradimeric assemblies, but ABCD1 interacts with ABCD2 in the BV-2 microglial cell line and in cell lysates, interaction analysis. ABCD1 and ABCD2 tetrameric assemblies remain unchanged during the catalytic cycle of the transporters |
751104 |
7.6.2.4 | more |
structure homology modeling using the the 2.85 A resolution rod form structure of ABCB10 (PDB ID 4AYX) as template |
750860 |
7.6.2.4 | more |
structure homology modeling using the the 2.85 A resolution rod form structure of ABCB10 (PDB ID 4AYX) as template, low similarity between ABCB10 and ABCD1 |
750860 |