  7.2.2.5 | physiological function |
ABC-type permease EfaCBA and Nramp-type transporters, MntH1 and MntH2, work collectively to promote cell growth under Mn-restricted conditions. The simultaneous inactivation of EfaCBA, MntH1 and MntH2 leads to more than 95% reductions in cellular Mn content, severe growth defects in serum and urine ex vivo, significant loss of virulence in Galleria mellonella, and virtually complete loss of virulence in rabbit endocarditis and murine catheter-associated urinary tract infection models. Dual inactivation of EfaCBA and MntH2 is sufficient to prompt maximal sensitivity to calprotectin, and for the loss of virulence in mammalian models |
-, 752000 |
