EC Number |
General Information |
Reference |
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7.2.2.3 | malfunction |
deletion of ENA1 has no effect on the tolerance to potassium and rubidium. Mutant cells are unable to grow on media containing higher concentrations of sodium and lithium cations |
719531 |
7.2.2.3 | metabolism |
important regulatory role of Ang-(1-7) in the action of angiotensin II on the Na+-ATPase activity of proximal tubule cells by activation of MAS receptor. The MAS receptor plays an important role as a regulator of the effects mediated by AT1 receptor on proximal tubule sodium reabsorption and renal sodium excretion, overview |
711011 |
7.2.2.3 | more |
Cer acts as a potent physiological modulator of the Na+-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta |
711013 |
7.2.2.3 | more |
increase in sodium reabsorption on the proximal tubule in essential hypertension. Na+-ATPase activity is enhanced in14-week-old but not in 6-week-old spontaneously hypertensive rats. correlation between AT1 receptor activation in spontaneously hypertensive rats and increased ouabaininsensitive Na+-ATPase activity. Ang II interacts with different receptors in spontaneously hypertensive rats and WKY wild-type rats. The AT1 receptor is responsible for activation in spontaneously hypertensive rats. Role of the AT2 receptor in counteracting the AT1 receptor to achieve hydroelectrolytic balance in normotensive rats |
711297 |
7.2.2.3 | more |
inosine-induced inhibition of Na+-ATPase activity could be involved in the increased renal sodium excretion during short periods of ischemia |
711004 |
7.2.2.3 | physiological function |
cardiomyocyte ATP1A2 is a target of anoxia-reoxygenation injury |
747446 |
7.2.2.3 | physiological function |
isoform KPA1 plays an important role in alkali and cold stress tolerance |
-, 720427 |
7.2.2.3 | physiological function |
isoform KPA2 plays an important role in alkali and cold stress tolerance |
-, 720427 |
7.2.2.3 | physiological function |
Na+ATPase is involved in Candida glabrata tolerance to high concentrations of Na+ and Li+ |
719531 |
7.2.2.3 | physiological function |
the enzyme functions as an electrogenic Na+ pump which transports only Na+ upon hydrolysis of ATP. Na+- and ATP-dependent H+ efflux from proteoliposomes, is driven by the electric potential generated by Na+-stimulated ATPase |
719166 |