EC Number   |
General Information |
Reference |
|---|
    5.4.99.1 | metabolism |
glutamate mutase and methylaspartase are the first two enzymes in the methylaspartate pathway, overview |
-, 714983 |
| 5.4.99.1 | more |
identification of the reactivating factor of glutamate mutase, MutL. MutL regenerates glutamate mutase and releases inactive coenzyme from the inactive glutamate mutase-adenosylcobalamine complex. Reactivation of the spontaneous inactive mutase (mutase-X-Cbl) and inactive form B12 binding with mutase (mutase-CNCbl) in presence of ATP and coenzyme B12 by MutL |
-, 748550 |
| 5.4.99.1 | more |
residue Glu117 and the arginine claw have a strong influence, and also residues Glu 214, Lys 322, Gln 147, Glu 330, Lys 326, and Met 294 play a catalytic role. The arginine claw keeps the intermediates in place and is probably responsible for the enantioselectivity. Glu 171 temporarily accepts a proton from the glutamyl radical intermediate and donates it back at the end of the reaction |
727661 |
| 5.4.99.1 | physiological function |
overexpression of glmS leads to a 4.9fold enhancement of intracellular vitamin B12 concentration |
716116 |
