EC Number   |
General Information |
Reference |
|---|
   5.3.2.1 | malfunction |
MIF expression contributes to cell proliferation, invasiveness and neo-angiogenesis of neuroblastoma, gastric, hepatocellularbladder, and breast carcinomas. MIF takes part in the pathogenesis of Alzheimer's disease and multiple sklerosis |
703331 |
| 5.3.2.1 | malfunction |
MIF is implicated in the pathogenesis of several inflammatory and autoimmune diseases |
702357 |
| 5.3.2.1 | physiological function |
MIF is involved in diverse biological processes, e.g. MIF glucocorticoid overriding activity, endotoxin lipopolysaccharide-induced TNF production, MIF-mediated stimulation of ERK1/2 MAP kinase and proliferation of serum-starved cells, MIF-mediated upregulation of arachidonic acid in macrophages, and Cox-2 activation |
702357 |
| 5.3.2.1 | physiological function |
MIF plays an essential role in both, innate and adaptive immune response. It is implicated in tumor growth and angiogenesis, an exerts an antagonistic effect against glucocorticoid immunosuppressive action, and shows glucorticoid overriding activity |
703331 |
