EC Number   |
General Information |
Reference |
|---|
   5.1.99.6 | malfunction |
a truncated form of the Arabidopsis epimerase lacking the PPOX domain is also fully active in the interconversion |
728528 |
| 5.1.99.6 | more |
the epimerase homologue is fused to the vitamin B6 salvage enzyme pyridoxine 5'-phosphate oxidase, PPOX. Plant epimerase homologs have an extra C-terminal domain that belongs to the pyridoxine/pyridoxamine phosphate oxidase (PPOX) family |
728528 |
| 5.1.99.6 | physiological function |
hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase recently identified as the products of the vertebrate Carkd (carbohydrate kinase domain) and Aibp (apolipoprotein AI-binding protein) genes, respectively |
726917 |
| 5.1.99.6 | physiological function |
NADH and NADPH undergo spontaneous and enzymatic reactions that produce R and S forms of NAD(P)H hydrates, which are not electron donors and inhibit various dehydrogenases. The highly conserved epimerase repairs the hydrates formed from NADH and NADPH in plants together with a highly conserved dehydratase targeted to multiple compartments |
728528 |
