Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search General Information

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 10 of 15 > >>
EC Number General Information Commentary Reference
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19evolution conversion of GlcA residues into the stereoisomer IdoA is mediated by two dermatan sulfate epimerases, DSE (DS-epi1) and DSEL (DS-epi2) 749050
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19malfunction a naturally occuring homozygous DSE mutation c.803C>T, pS268L, causes musculocontractural type of Ehlers-Danlos syndrome, MCEDS. The mutant enzymes shows a loss of activity towards partially desulfated dermatan sulfate, patient-derived fibroblasts also show a significant reduction in epimerase activity. Dermatan sulfate disaccharides are reduced, while chondroitin sulfate disaccharides are increased in cultured fibroblasts. Stable transfection of patient fibroblasts with a DSE expression vector increases the amount of secreted dermatan sulfate disaccharides 727608
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19malfunction DS-epi1 deficiency alters skin morphology, collagen fibril ultrastructure, and skin tensile strength, phenotype, overview 705699
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19malfunction DS-epi2 is genetically linked to bipolar disorder, which suggests that the dermatan sulfate domains generated by a defective enzyme may be involved in the etiology of the disease 704644
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19metabolism the enzyme catalyzes a step in dermatan sulfate and chondroitin sulfate biosynthesis, pathway overview 727608
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19metabolism the enzyme catalyzes a step in dermatan sulfate and chondroitin sulfte biosynthesis, pathway overview 727608
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19metabolism the enzyme is involved in the chondroitin/dermatan sulfate biosynthesis, overview 749050
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19more enzyme Dsel harbors a C-terminal sulfotransferase-like domain 749120
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19more polysaccharide processivity opens up the possibility for an efficient formation of long stretches of IdoA, which have been shown to be of major importance for CS/DS regulatory effect on collagen fibrillization 747527
Show all pathways known for 5.1.3.19Display the word mapDisplay the reaction diagram Show all sequences 5.1.3.19physiological function conversion of GlcA residues into the stereoisomer IdoA is mediated by two dermatan sulfate epimerases, DSE (DS-epi1) and DSEL (DS-epi2), modification reactions in chondroitin/dermatan sulfate biosynthesis, overview 749050
Results 1 - 10 of 15 > >>