EC Number   |
General Information |
Reference |
|---|
    5.1.3.13 | evolution |
Archaea synthesize nucleotide-activated rhamnose by a pathway similar to that employed by Bacteria and distinct from that used by Eukarya and viruses |
-, 749151 |
| 5.1.3.13 | evolution |
structural comparison of the enzyme structure with RfbC homologues shows that the key active-site residues are conserved across kingdoms. RmlC-like epimerases belongs to the diverse cupin superfamily |
-, 746670 |
| 5.1.3.13 | malfunction |
disruption of rmbC results in fragmented mycelia that quickly convert into gray pigmented spores |
-, 726772 |
| 5.1.3.13 | malfunction |
rhamnose and N-acetyl-galactosamine are not detected, and fucose is greatly diminished in the rmlC mutant (transposon pLOF/Sp inserted into rmlC (TDP-4-keto-6-deoxy-D-glucose 3,5-epimerase) compared with that in the wild-type strain) |
715361 |
| 5.1.3.13 | malfunction |
the expression of the rhamnose biosynthetic genes by RNAi results in significant reductions in dTDP-rhamnose, but has no effect on the biosynthesis of a closely related sugar, ascarylose, found in the ascaroside pheromones. RNAi against rml-3 does not affect embryonic or larval development |
747027 |
| 5.1.3.13 | metabolism |
Archaea synthesize nucleotide-activated rhamnose by a pathway similar to that employed by Bacteria and distinct from that used by Eukarya and viruses. The pathwayto synthesize nucleotide-activated rhamnose involves Agl11 as a glucose-1-phosphate thymidylyltransferase, Agl12 as a dTDP-glucose-4,6-dehydratase, Agl13 as a dTDP-4-dehydro-6-deoxy-glucose-3,5-epimerase, and Agl14 as a dTDP-4-dehydrorhamnose reductase |
-, 749151 |
| 5.1.3.13 | metabolism |
biosynthesis of dTDP-L-rhamnose: RML-1 activates glucose 1-phosphate in the presence of either dTTP or UTP to yield dTDP-glucose or UDP-glucose, respectively. RML-2 is a dTDP-glucose 4,6-dehydratase, converting dTDP-glucose into dTDP-4-keto-6-deoxyglucose. And coincubation of dTDP-4-keto-6-deoxyglucose with RML-3 (3,5-epimerase) and RML-4 (4-keto-reductase) produces dTDP-rhamnose. A co-regulated protein, RML-5, forms a complex with RML-4. Rhamnose biosynthesis may play an important role in hypodermal development or the production of the cuticle or surface coat during molting |
747027 |
| 5.1.3.13 | metabolism |
dTDP-4-dehydrorhamnose 3,5-epimerase is an enzyme which may be associated with the cellulose synthesis-reducing effect of the mutation in strain K3 |
703046 |
| 5.1.3.13 | metabolism |
the biosynthetic pathway used to form the activated L-rhamnose donor dTDP-L-rhamnose consists of four enzymes, RfbA, RfbB, RfbC and RfbD. RfbC catalyzes the third reaction, a double epimerization producing dTDP-6-deoxy-L-lyxo-4-hexulose (dTDP-4-dehydro-L-rhamnose) |
-, 746670 |
| 5.1.3.13 | metabolism |
the enzyme from the doxorubicin biosynthesis gene cluster is involved in the biosynthesis of dTDP-L-daunosamine, pathway overview. It does not compensate for the other dTDP-4-keto-6-deoxyglucose 3,5-epimerase encoded by gene rmbC. Although dnmU and rmbC encode for similar functional proteins, their native roles in their respective biosynthetic pathways in vivo are specific and independent of one other |
-, 726772 |
