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Results 1 - 10 of 31 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19evolution plants have extensively diversified their arsenal of labdane-related diterpenoids (LRDs), in part via gene duplication and neo-functionalization of the ancestral ent-kaurene synthase (KS) required for gibberellin metabolism. Ricinus communis contains 4 RcKSL isozymes, molecular phylogenetic analysis indicates that RcKSL1 is significantly more closely related to dicotyl ent-kaurene synthases (KSs), while the other three, RcKSL2-4, cluster separately. RcKSL2-4 are in close proximity to each other, within a region of 65 kb, with RcKSL2 and 4 occurring as a tandem gene pair. RcKSL1 is the only isozyme to react with ent-CPP producing small amounts of ent-kaurene, and is referred to as RcKS1. Both RcKSL2 and RcKSL3 also are selectively reacting with ent-CPP with RcKSL2 producing primarily ent-trachylobane (70%) as well as smaller amounts of ent-kaurene (30%), and RcKSL3 producing ent-sandaracopimaradiene (94%) (EC 4.2.3.29) along with small amounts of ent-labdatriene (3%) and ent-pimaradiene (3%). RcKSL4 seems to be inactive, with no products evident from any substrate, but upon synthesis of a codon-optimized gene for the corrected aa sequence and functional analysis, RcKSL4 selectively reacts with ent-CPP and produces largely ent-beyerene (95%) along with very small amounts of ent-atiserene (4%) and ent-kaurene (1%). The enzymes belong to the terpene synthase family 748876
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19evolution PpCPS/KS is a multiproduct enzyme. It is one of the evolutionary earliest occurring plant diterpene synthases. Thus, PpCPS/KS may have been a multiproduct platform for later evolved diterpene synthases in plants 749011
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19evolution production of ent-kaurene as a precursor for important signaling molecules such as the gibberellins seems to have arisen early in plant evolution, with corresponding cyclase(s) present in all land plants (i.e., embryophyta). The relevant enzymes seem to represent fusion of the class II diterpene cyclase that produces the intermediate ent-copalyl diphosphate (ent-CPP) and the subsequently acting class I diterpene synthase that produces ent-kaurene, although the bifunctionality of the ancestral gene is only retained in certain early diverging plants, with gene duplication and sub-functionalization leading to distinct ent-CPP synthases and ent-kaurene synthases (KSs) generally observed 747870
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19evolution the enzyme is a class I bacterial diterpene cyclase -, 749301
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19evolution the enzyme is a class I diterpene cyclase -, 747507
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19evolution the enzyme is a class I diterpene synthase 745584
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19evolution the enzyme is a monofunctional class I diTPS 746448
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19malfunction caulonemal differentiation in a Physcomitrella patens mutant with a disrupted bifunctional ent-copalyl diphosphate synthase/ent-kaurene synthase (PpCPS/KS) gene is suppressed under red light, and is recovered by application of ent-kaurene and ent-kaurenoic acid. Although avoidance of the blue light source is not observed in the ent-kaurene deficient mutant protonemata, chloronemal growth toward a blue-light source in the mutant is suppressed by application of ent-kaurenoic acid, and the growth is rescued to that in the wild type 749028
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19malfunction CPS/KS disruption mutant lines have defect in protonemal development. The differentiation of chloronemata to caulonemata is suppressed in the CPS/KS knockout mutants 706338
Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.19malfunction CPS/KS disruption mutant lines have defect in protonemal development. The differentiation of chloronemata to caulonemata iss suppressed in the CPS/KS knockout mutants 706338
Results 1 - 10 of 31 > >>