EC Number |
General Information |
Reference |
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4.2.1.49 | malfunction |
L-His uptake triggers biofilms efficiently in wild-type Acinetobacter baumannii, but no effect is observed in urocanase and OmpA mutants, while a slight increase is observed in a CarO-deficient strain |
-, 716047 |
4.2.1.49 | malfunction |
L70P and R450C mutations in the coding region of the UROC1 gene in a girl with urocanic aciduria presenting with mental retardation and intermittent ataxia. Both mutations cannot produce a fully functional enzyme, L70P substitution implies the disruption of an alpha-helix in the N-terminus, which alters its properties and therefore, its function. The R450C change renders impossible any interaction between urocanase and its substrate and loses its enzyme activity |
705076 |
4.2.1.49 | metabolism |
the enzyme is involved in histidine degradation and is essential for the catabolic conversion of urocanate to 4-imidazolone-5-propionate, which finally yields glutamate and further glutamine and tricarboxylic acid cycle intemediates such as 2-oxo-pentanedioate |
-, 749275 |
4.2.1.49 | metabolism |
urocanase plays a central functional role in metabolism of histidine. The histidine degradation pathway occurs via urocanase and leads to the production of purines and pyrimidines |
-, 716047 |