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Results 1 - 4 of 4
EC Number General Information Commentary Reference
Show all pathways known for 4.2.1.49Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.49malfunction L-His uptake triggers biofilms efficiently in wild-type Acinetobacter baumannii, but no effect is observed in urocanase and OmpA mutants, while a slight increase is observed in a CarO-deficient strain -, 716047
Show all pathways known for 4.2.1.49Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.49malfunction L70P and R450C mutations in the coding region of the UROC1 gene in a girl with urocanic aciduria presenting with mental retardation and intermittent ataxia. Both mutations cannot produce a fully functional enzyme, L70P substitution implies the disruption of an alpha-helix in the N-terminus, which alters its properties and therefore, its function. The R450C change renders impossible any interaction between urocanase and its substrate and loses its enzyme activity 705076
Show all pathways known for 4.2.1.49Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.49metabolism the enzyme is involved in histidine degradation and is essential for the catabolic conversion of urocanate to 4-imidazolone-5-propionate, which finally yields glutamate and further glutamine and tricarboxylic acid cycle intemediates such as 2-oxo-pentanedioate -, 749275
Show all pathways known for 4.2.1.49Display the word mapDisplay the reaction diagram Show all sequences 4.2.1.49metabolism urocanase plays a central functional role in metabolism of histidine. The histidine degradation pathway occurs via urocanase and leads to the production of purines and pyrimidines -, 716047
Results 1 - 4 of 4