EC Number   |
General Information |
Reference |
|---|
    4.2.1.113 | evolution |
o-succinylbenzoate synthase is a member of the enolase superfamily |
729241 |
| 4.2.1.113 | evolution |
o-succinylbenzoate synthase is a member of the enolase superfamily, there are significant differences in structure and conformational flexibility between Thermobifida fusca OSBS and other members of the enolase superfamily. The 20s loop, a flexible loop in the active site that permits ligand binding and release in most enolase superfamily proteins, has a four-amino acid deletion and is well-ordered in Thermobifida fusca OSBS. The flexibility of a different region allows the substrate to enter from the other side of the active site |
729241 |
| 4.2.1.113 | evolution |
the enzyme belongs to the NSAR/OSBS subfamily of enzymes, the enzyme from Exiguobacterium sp. shows both o-succinylbenzoate synthase and N-succinylamino acid racemization activities. The N-succinylamino acid racemization activity originates as a promiscuous activity in an ancestor of the NSAR/OSBS subfamily. ExiOSBS diverged from the NSAR/OSBS subfamily before NSAR emerged as a biologically relevant activity |
-, 729149 |
| 4.2.1.113 | evolution |
the enzyme belongs to the o-succinylbenzoate synthase (OSBS) family, which is part of the enolase superfamily. Some enzymes in the OSBS family catalyze another reaction, N-succinylamino acid racemization (NSAR). NSARs cannot be segregated into a separate family because their sequences are highly similar to those of known OSBSs, and many of them have both OSBS and NSAR activities. Phylogenetic and sequence analysis |
729216 |
| 4.2.1.113 | evolution |
the evolution of catalytically promiscuous enzymes like those from the N-succinylamino acid racemase/o-succinylbenzoate synthase (NSAR/OSBS) subfamily can reveal mechanisms by which new functions evolve. Additional sites influence the evolution of NSAR reaction specificity in the NSAR/OSBS subfamily |
-, 747149 |
| 4.2.1.113 | metabolism |
o-succinylbenzoate synthase catalyzes a step in menaquinone biosynthesis |
729241 |
| 4.2.1.113 | metabolism |
O-succinylbenzoate synthase plays a major role in the shikimate pathway |
-, 746774 |
| 4.2.1.113 | metabolism |
the enzyme is important in the menaquinone biosynthesis |
-, 729005 |
| 4.2.1.113 | metabolism |
the enzyme is involved in menaquinone synthesis |
-, 729149 |
| 4.2.1.113 | metabolism |
the enzyme is required for menaquinone biosynthesis |
729216 |
