EC Number   |
General Information |
Reference |
|---|
    4.1.3.30 | evolution |
the 2-methylcitrate cycle enzymes have been acquired via horizontal gene transfer, PrpB phylogenetic analysis, overview |
728336 |
| 4.1.3.30 | malfunction |
a plate confrontation assay does not show a difference between the wild-type and the DELTAmcl deletion strain in antagonism towards Botrytis cinerea. But the DELTAmcl strain displays reduced antagonism towards Botrytis cinerea based on a secretion assay. An in vitro root colonization assay shows that the DELTAmcl strain has reduced ability to colonize Arabidopsis thaliana roots, which results in reduced induction of systemic resistance towards Botrytis cinerea. phenotype, overview. The DELTAmcl strain showed significantly reduced numbers of germinating conidia and delayed conidial pigmentation, as well as decreased tolerance to osmotic stress |
-, 728261 |
| 4.1.3.30 | malfunction |
absence of MCL activity results in the accumulation of methylisocitrate as a metabolic dead end product arising from the stoichiometric consumption of oxaloacetate by propionyl-CoA, phenotype, overview. Isocitrate lyases are essential for survival on both acetate and propionate because of its methylisocitrate lyase activity. Lack of methylisocitrate lyase activity converts the cell methylcitrate cycle into a dead end pathway that sequesters tricarboxylic acid (TCA) cycle intermediates into methylcitrate cycle intermediates, depletes gluconeogenic precursors, and results in defects of membrane potential and intrabacterial pH |
728701 |
| 4.1.3.30 | malfunction |
an enzyme-disruption mutant prpb-ko shows accumulation of 2-methylcitrate cycle intermediate metabolites, enzyme substrates accumulate in parasites deficient in the enzyme and its absence confers increased sensitivity to propionic acid |
728336 |
| 4.1.3.30 | malfunction |
the DELTAMCL1 strains fail to grow on propionate but exhibit no major changes in other traits, double deletion of both isocitrate lyase 1 and methylisocitrate lyase 1 cause significantly reduced virulence on host plants |
-, 703509 |
| 4.1.3.30 | metabolism |
role of the methylcitrate cycle in propionate metabolism |
-, 728261 |
| 4.1.3.30 | metabolism |
the enzyme is involved in the methylcitric acid cycle |
-, 747131 |
| 4.1.3.30 | physiological function |
MCL1 is required for the methylcitrate cycle in Gibberella zeae |
-, 703509 |
| 4.1.3.30 | physiological function |
methylisocitrate lyase is a signature enzyme of the methylcitrate cycle, which is required for propionate metabolism, for secondary metabolite production and for virulence in bacteria and fungi. The enzyme is required in propionate resistance, growth, conidial pigmentation and germination, and abiotic stress tolerance |
-, 728261 |
| 4.1.3.30 | physiological function |
Mycobacterium tuberculosis isocitrate lyases are catalytically bifunctional isocitrate and methylisocitrate lyases required for growth on even and odd chain fatty acids |
728701 |
