    4.1.2.25 | physiological function |
in isoform folA1 conditional mutant germlings incubated at 30°C for 16 h, the number of nuclei at is comparable with that of wild type germlings. At the restrictive temperature of 44°C, however, 60% of the conidiospores have a single nucleus while wild-type germlings normally undergo two or three nuclear divisions under these conditions. Mutant cells exit from M phase, arrest at 44°C, traverse mitosis and G1 phase, and arrest in S phase in the presence of hydroxyurea. The addition of 1.8 mM folic acid does not improve growth of folA1 mutant strains at 44°C, nor does it improve their growth at 30°C. A mutation in folA can suppress fungal transcription factor crzAD calcium toxicity |
727583 |
