EC Number   |
General Information |
Reference |
|---|
   3.9.1.3 | malfunction |
cell proliferation is inhibited and cell apoptosis is significantly increased following knockdown of 14 kDa phosphohistidine phosphatase |
736912 |
| 3.9.1.3 | malfunction |
decreased expression of PHPT-1 in human CD4 T cells results in an increase in KCa3.1 channel activity and increases Ca2+ influx and proliferation after T cell receptor activation |
737157 |
| 3.9.1.3 | malfunction |
DELTAsixA cells have lower intracellular potassium levels than wild-type cells |
-, 757556 |
| 3.9.1.3 | malfunction |
depletion of the enzyme significantly reduces glucose- and mitochondrial fuel- but not KCl-induced insulin secretion |
735423 |
| 3.9.1.3 | malfunction |
enzyme downregulation does not induce cell death, but significantly increases the acetylcholine content in SN-56 cells |
735859 |
| 3.9.1.3 | malfunction |
enzyme knockdown in highly metastatic lung cancer CL1-5 cells inhibits migration and invasion in vitro, but does not alter cell proliferation rates, while enzyme overexpression in H1299 cells promotes migration and invasion in vitro, but again does not alter cell proliferation |
736722 |
| 3.9.1.3 | malfunction |
Pgam5-/- T cells cause accelerated and more severe Graft versus host disease (GvHD) in mice |
757649 |
| 3.9.1.3 | malfunction |
PHP14 knockdown impairs Arp3 localization at the leading edge of lamellipodia, as well as lamellipodia formation |
756371 |
| 3.9.1.3 | malfunction |
PHPT-1(-/-) mice exhibit neonatal hyperinsulinemic hypoglycemia due to impaired trafficking of K(ATP) channels to the plasma membrane in pancreatic beta-cells in response to low glucose and leptin. The defect in K(ATP) channel trafficking in PHPT-1(-/-) beta-cells is due to the failure of PHPT-1 to directly activate transient receptor potential channel 4 (TRPC4), resulting in decreased Ca2+ influx and impaired downstream activation of AMPK |
756554 |
| 3.9.1.3 | metabolism |
LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic |
757801 |
