EC Number   |
General Information |
Reference |
|---|
    3.8.1.2 | evolution |
2-HADs can be classified into two phylogenetically distinct groups according to their substrate specificity. Group II consists of only L-HADs, which selectively act on L-2-haloalkanoic acids to produce D-2-hydroxyacids. HADIIBSW is evolutionarily distinct from previously characterized L-HADs, sharing only 34% identity with L-HAD (DehRhb) from a Rhodobacteraceae family bacterium UDC319 as the closest relative |
-, 735151 |
| 3.8.1.2 | evolution |
the enzyme belongs to the Group II family |
719748 |
| 3.8.1.2 | evolution |
the enzyme belongs to the HAD enzyme superfamily, which use an aspartate group as the nucleophile in their catalytic mechanism.. The HAD superfamily of enzymes also includes phosphate monoesterases, ATPases, phosphonoacetaldehyde hydrolases and phosphomutases |
733826 |
| 3.8.1.2 | evolution |
the enzyme belongs to the HAD superfamily |
-, 719121 |
| 3.8.1.2 | more |
folding of the DehRhb monomer and active site structure with catalytic residue Asp18, overall structure modeling. The halogen cradle in enzyme DehRhb is formed by the side chains of Phe47, Ile51, Phe66, Asn125 and Trp185 |
733826 |
| 3.8.1.2 | physiological function |
DEH99 is a (S)-2-haloacid dehalogenase, which can degrade (S)-2-chloropropionic acid, (S)-2-bromopropionic acid, and iodoacetic acid |
719748 |
