EC Number   |
General Information |
Reference |
|---|
    3.7.1.2 | malfunction |
an Arabidopsis thaliana short-day sensitive cell death1 (sscd1) mutant displays a spontaneous cell death phenotype under short-day conditions, disruption of FAH leads to cell death, phenotype overview. The spontaneous cell death phenotype of the sscd1 mutant is completely eliminated by further knockout of the gene encoding the putative homogentisate dioxygenase, which catalyzes homogentisate into maleylacetoacetate (the antepenultimate step) in the Tyr degradation pathway. Treatment of Arabidopsis wild-type seedlings with succinylacetone, an abnormal metabolite caused by loss of FAH in the Tyr degradation pathway, mimicks the sscd1 cell death phenotype |
734967 |
| 3.7.1.2 | malfunction |
lethal phenotype of the short-day sensitive cell death1 (sscd1) seedlings resulting from the loss of fumarylacetoacetate hydrolase |
758089 |
| 3.7.1.2 | malfunction |
more than 100 mutations in the gene encoding fumarylacetoacetate hydrolase cause hereditary tyrosinemia type I, a metabolic disorder characterized by elevated blood levels of tyrosine |
757221 |
| 3.7.1.2 | malfunction |
the sscd1 mutant is hypersensitive to salt stress. The sscd1 mutant shows more accumulation of reactive oxygen species (ROS) and less up-regulation of some ROS-scavenging genes such as ASCORBATE PEROXIDASE 2 and COPPER/ZINC SUPEROXIDE DISMUTASE 1 compared with wild type under salt stress. The sscd1 mutant exhibits hypersensitivity to oxidative stress compared with wild type enzyme. Loss of fumarylacetoacetate hydrolase in sscd1 mutant leads to the accumulation of Tyr degradation intermediates, which impairs the up-regulation of some ROS-scavenging genes under salt stress, causing more accumulation of ROS, resulting in the hypersensitivity of sscd1 to salt stress |
-, 758094 |
| 3.7.1.2 | metabolism |
fumarylacetoacetate hydrolase hydrolyzes fumarylacetoacetate to fumarate and acetoacetate, the final step in the tyrosine degradation pathway that is essential for plant survival under short-day conditions |
734967 |
| 3.7.1.2 | metabolism |
fumarylacetoacetate hydrolase is a metabolic enzyme that participates in phenylalanine and tyrosine catabolism and can catalyze the hydrolytic cleavage of carbon-carbon bonds in a variety of diketo acid substrates. Fumarylacetoacetate hydrolase catalyzes the hydrolytic cleavage of a carbon-carbon bond in fumarylacetoacetate to yield acetoacetate and fumarate as the final step in tyrosine degradation |
-, 734103 |
| 3.7.1.2 | physiological function |
final step in the Tyr degradation pathway |
-, 758094 |
| 3.7.1.2 | physiological function |
involved in aromatic amino acid metabolism |
706809 |
| 3.7.1.2 | physiological function |
the enzyme catalyzes the last step in the Tyr degradation pathway |
758089 |
| 3.7.1.2 | physiological function |
the enzyme is essential for the degradation of aromatic amino acids as well as for the cleavage of carbon-carbon bonds in metabolites or small organic compounds |
-, 755976 |
