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EC Number General Information Commentary Reference
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11evolution the enzyme belongs to the DHH family of phosphoesterases. Polyphosphatases Ppx1, Ppn1, Ddp1, and Ppn2 show distinct substrate specificities and levels of endo- and exopolyphosphatase activities, as well as distinct patterns of stimulation by metal ions. The differences in the mode of polyphosphate hydrolysis, substrate specificity, metal ion dependence and cell localization suggest distinct roles of these enzymes in yeast -, 756125
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11evolution the enzyme belongs to the PPX/GppA phosphatase family (pfam02541) that consists of PPX (EC 3.6.1.11) and guanosine pentaphosphate phosphohydrolase (GppA, EC 3.6.1.40) enzymes -, 755724
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11evolution the exopolyphosphatase belongs to the ASKHA protein superfamily 755891
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11evolution the Nudix superfamily (Pfam PF00293) is found in archaea, bacteria, eukaryotes and viruses and includes pyrophosphohydrolases of nucleotide sugars and alcohols, nucleoside and deoxynucleoside triphosphates ([d]NTPs), dinucleoside polyphosphates, dinucleotide coenzymes and capped RNAs. Trypanosoma brucei has five Nudix hydrolases -, 756231
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11malfunction analysis of single ppx- or ppk- mutants and of the double mutant, demonstrate a relationship between these genes and the survival capacity 755891
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11malfunction bacteria lacking PPX exhibit increased resistance to complement-mediated killing. Loss of PPX leads to decrease in alternative pathway activation on bacterial surface 712478
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11malfunction deficiency of exopolyphosphatase results in decelerated growth during logarithmic-phase in axenic cultures, and tolerance to the cell wall-active drug isoniazid. The enzyme-deficient mutant shows a significant survival defect in activated human macrophages and reduced persistence in the lungs of guinea pigs -, 720842
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11malfunction PPX1 genetic ablation does not produce a dramatic phenotype -, 711604
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11metabolism inorganic polyphosphate, exopolyphosphatase, and Pho84-like transporters may be involved in copper resistance in Metallosphaera sedula DSM 5348. Existence of a polyphosphate-dependent copper-resistance system that may be of great importance in the adaptation of this thermoacidophilic archaeon to its harsh environment -, 755915
Show all pathways known for 3.6.1.11Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.11metabolism polyphosphate kinase (PPK) is the principal source of polyphosphate in most bacteria, whereas exopolyphosphatases (PPX) are mainly responsible for the degradation of polyphosphate -, 755724
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