EC Number   |
General Information |
Reference |
|---|
    3.5.4.25 | malfunction |
NbRibA-silenced plants show slightly dwarf phenotypes, levels of endogenous riboflavin and its derivatives FMN and FAD are decreased in NbRibA-silenced Nicotiana benthamiana plants. Silencing of NbRibA compromises not only hypersensitive response cell death, but also the NO and reactive oxygen species production induced by INF1 elicitin and a constitutively active form of NbMEK2, and also induces high susceptibility to oomycete Phytophthora infestans and ascomycete Colletotrichum orbiculare. Compromised radical production and hypersensitive response cell death induced by INF1 in NbRibA-silenced leaves are rescued by adding riboflavin, FMN or FAD |
716533 |
| 3.5.4.25 | malfunction |
pigmentation defect due to mutation of gch2 |
757951 |
| 3.5.4.25 | metabolism |
3,4-dihydroxy 2-butanone 4-phosphate synthase, DHBPS EC 4.1.99.12, and GTP cyclohydrolase-II, GTPCH-II, are the two initial enzymes involved in riboflavin biosynthesis pathway, which is essential for the pathogen |
716058 |
| 3.5.4.25 | metabolism |
critical protein in the pteridine biosynthetic pathway |
757951 |
| 3.5.4.25 | metabolism |
GCH II catalyzes the first committed step in the riboflavin biosynthetic pathway |
-, 712085 |
| 3.5.4.25 | metabolism |
GTP cyclohydrolase II catalyzes the first committed step in the biosynthesis of riboflavin |
734013 |
| 3.5.4.25 | metabolism |
GTP cyclohydrolase II catalyzes the first dedicated step in the biosynthesis of riboflavin |
711974 |
| 3.5.4.25 | metabolism |
the bifunctional enzyme, guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase, participates in the biosynthesis of flavin |
716533 |
| 3.5.4.25 | metabolism |
the enzyme is essential for pathogens. The enzyme can regulate its catalytic activity depending on the redox environment |
-, 757510 |
| 3.5.4.25 | metabolism |
the enzyme is involved in riboflavin biosynthesis and in biosynthesis of toxoflavin (a phytotoxin that contributes the virulence of this phytopathogen) |
-, 757365 |
