   3.5.2.1 | evolution |
the enzyme belongs to a protein family that consists of only cyanuric acid hydrolase (CAH) and barbiturase. CAH and barbiturase enzymes act on structurally analogous 6-membered ring substrates, yet each enzyme is specific and does not react with the other's substrate. While most organisms utilize a reductive pyrimidine degradation pathway, some actinobacteria use barbiturase in an oxidative catabolic pathway. Unlike barbiturase, cyanuric acid hydrolases are more broadly distributed throughout bacteria and fungi. The CAH/barbiturase family includes 169 different sequences of Actinobacteria, phylogenetic analysis and tree, overview |
755842 |
