EC Number   |
General Information |
Reference |
|---|
  3.5.1.60 | evolution |
the enzyme is a cysteine amidase that belongs to the N-terminal nucleophile (Ntn) family of enzymes and is characterized by a conserved amino acid catalytic triad Cys, Arg, and Asp |
733664 |
| 3.5.1.60 | evolution |
the enzyme is a cysteine hydrolase belonging to the N-terminalnucleophile (Ntn) family of enzymes |
734845 |
| 3.5.1.60 | malfunction |
effects of pretreatment with the NAAA inhibitor AM11095 on nicotine-related effects in the rat mesolimbic dopamine system, phenotype, detailed overview |
-, 754903 |
| 3.5.1.60 | malfunction |
enzyme inhibitors may attenuate heat hyperalgesia and mechanical allodynia caused by local inflammation or nerve damage in animal models of pain and inflammation |
734845 |
| 3.5.1.60 | malfunction |
N-acylethanolamine acid amidase inhibitor ARN077 suppresses inflammation and pruritus in a mouse model of allergic dermatitis |
-, 754356 |
| 3.5.1.60 | malfunction |
pharmacological inhibitors of NAAA activity exert profound analgesic and antiinflammatory effects |
755270 |
| 3.5.1.60 | malfunction |
prevention against cartilage degeneration by i.p. injection of enzyme inhibitor F215 in osteoarthritis rats |
755003 |
| 3.5.1.60 | more |
residues Leu325 and Thr335 are catalytically important for isozyme A, and the latter one is indispensable for the enzyme activity of NAAA |
752811 |
| 3.5.1.60 | more |
structure analysis of the enzme in complex with myristate, substrate binding structure, overview. The enzyme must disrupt the membrane to reach its embedded substrate, and helices alpha3 and alpha6 are likely candidates for this function |
755270 |
| 3.5.1.60 | more |
the catalytic triad, is formed by cysteine, aspartate and arginine |
734562 |
