EC Number   |
General Information |
Reference |
|---|
   3.5.1.52 | evolution |
phylogenetic analysis of acidic PNGases, yeast PNGases are diverse and distantly related from filamentous fungi PNGases in the phylogenetic tree |
-, 734113 |
| 3.5.1.52 | evolution |
PNGases are classified into two types based on their optimum pH: neutral or cytosolic PNGase (cPNGase) and acidic PNGase (aPNGase). cPNGase is found ubiquitously in eukaryotic cells, while aPNGase is found mainly in plants |
-, 753034 |
| 3.5.1.52 | evolution |
the enzyme from Dictyostelium discoideum is a member of transglutaminase (TG) -like superfamily and shows presence of a common transglutaminase core domain and sequence homology with the known PNGases, the tertiary structure matches with the mouse PNGase. DdPNGase possess the catalytic triad residues Cys210, His237 and Asp252, corresponding to the conserved core residues of other PNGases. DdPNGase also possess the corresponding Trp239 and Trp248, Arg229 and Glu241 conserved residues which possibly are essential for catalysis |
-, 733566 |
| 3.5.1.52 | malfunction |
an enzyme knockout results in small sized aggregates, all of which do not form fruiting bodies. Knockout mutants show defect in aggregation, penotypes, overview |
-, 733566 |
| 3.5.1.52 | malfunction |
homozygous deletion mutants show developmental defect |
720808 |
| 3.5.1.52 | malfunction |
in yeast cells, the absence of cytoplasmic PNGase (Png1) results in significant reduction of the levels of free oligosaccharidesfound in the cytosol, suggesting that the majority, if not all, of the free oligosaccharidesin yeast are generated from misfolded glycoproteins in a PNGase-dependent manner. Phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are defect in ERAD, but no growth/viability defects |
-, 754027 |
| 3.5.1.52 | malfunction |
mutations in png-1 result in an increase in axon branching during morphogenesis of the vulval egg-laying organ and egg-laying behavior changes, neuronal defects include an increase in the branched morphology of the VC4 and VC5 egg-laying neurons as well as inappropriate branches from axons that run adjacent to the vulva |
712830 |
| 3.5.1.52 | malfunction |
phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are abnormal axon branching of VC4/VC5 egg-laying neurons, and egg-laying behaviour defect |
754027 |
| 3.5.1.52 | malfunction |
phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are global developmental delay, movement disorder, and hypotonia |
754027 |
| 3.5.1.52 | malfunction |
phenotypes/pathological conditions caused by mutations in gene orthologues of cytoplasmic PNGase are not detected |
754027 |
