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Results 1 - 8 of 8
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.103malfunction disruption of mshB in Mycobacterium smegmatis results in decreased production of mycothiol (5–10% of the parent strain mc2155) but does not abolish mycothiol synthesis completely. Complementation of the MshB2 mutants with the mshB gene results in increased mycothiol production towards the exponential and stationary phases of the bacterial growth cycle. The results suggest that another enzyme is capable of mycothiol biosynthesis by providing N-acetylglucosaminylinositol deacetylation activity in the absence of MshB 700027
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.103malfunction GlcNAc-Ins is absent in mycothiol-deficient mutant strain 49. This strain can concentrate GlcNAc-Ins from the medium and convert it to mycothiol -, 698559
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.103metabolism Actinobacteria use the unique thiol mycothiol (MSH) as their primary reducing agent and in the detoxification of xenobiotics. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is the metal-dependent deacetylase that catalyzes the deacetylation of N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside, the committed step in MSH biosynthesis -, 752756
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.103metabolism the enzyme is involved in the biosynthesis of mycothiol (MSH), a protective low molecular weight thiol present only in Mycobacterium tuberculosis and other actinomycetes 734822
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.103metabolism the zinc-based deacetylase catalyses a step in the mycothiol biosynthetic pathway that involves the deacetylation of 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-D-myo-inositol via cleavage of an amide bond, to 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-D-myo-inositol and acetate 732997
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.103metabolism the zinc-based deacetylase catalyzes the fourth step in mycothiol biosynthesis, the deacetylation of N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside to form 1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside and acetate 733518
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.103more configuration strongly suggests that Asp15 acts both as a general base catalyst in the nucleophilic attack of water on the amide carbonyl C atom and in its protonated form acts as a general acid to protonate the amide N atom. Residue Tyr142 is involved in a conformational change on substrate binding and contributes to the oxyanion hole that stabilizes the tetrahedral intermediate 732997
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.103more the core structure of MshB contains two homologous domains comprised of two alpha-helices sandwiched by a five-stranded beta-sheet, three-dimensional structure of MshB, Zn-MshB, PDB ID 1Q74 733518
Results 1 - 8 of 8