EC Number |
General Information |
Reference |
---|
3.4.24.B17 | malfunction |
expression of doxorubicin resistance protein B alone or doxorubicin resistance protein AB together in FtsH-deficient cells results in growth inhibition |
-, 734211 |
3.4.24.B17 | metabolism |
the enzyme facilitates refolding of previously misassembled membrane protein doxorubicin resistance protein AB |
-, 734211 |
3.4.24.B17 | physiological function |
dependence of degradation rates on ATP hydrolysis rates is highly nonlinear. At least, about 20 ATP hydrolysis events need to be accumulated per minute for degradation to occur, but once exceeding the threshold, FtsH tightly couples ATP hydrolysis to degradation in a highly cooperative manner (Hill coefficinet for ATP is 4-5). The degradation rates steeply increase and saturate at the ATP hydrolysis rates far below the maxima. During the steep increase, FtsH efficiently utilizes ATP hydrolysis for degradation, consuming only 40-60% of the total ATP cost measured at the maximal ATP hydrolysis rates |
755341 |
3.4.24.B17 | physiological function |
FtsH controls lipopolysaccharide biosynthesis by proteolysis of LpxC |
-, 719722 |
3.4.24.B17 | physiological function |
FtsH is necessary for the processing of colicinsD and E3 during their import into the cytoplasm |
-, 719955 |
3.4.24.B17 | physiological function |
FtsH plays a role in phage lambda infection, serves a dual function in regulation of lipopolysaccharide biosynthesis and is involved in survival upon stress conditions like heat shock or osmotic stres |
718996 |
3.4.24.B17 | physiological function |
FtsH plays a role in phage lambda infection, serves a dual function in regulation of lipopolysaccharide biosynthesis and is involved in survival upon stress conditions like heat shock or osmotic stress |
718996 |
3.4.24.B17 | physiological function |
the enzyme is essential for the differentiation of matrix producers and biofilm formation |
-, 734710 |
3.4.24.B17 | physiological function |
uncomplexed phage shock protein C is deleterious to the bacterial cell and FtsH acts as an important quality control mechanism to remove it |
-, 719733 |