EC Number   |
General Information |
Reference |
|---|
   3.4.24.87 | malfunction |
a severe functional deficiency of ADAMTS13 (activity lower than 10%) is associated with thrombotic thrombocytopenic purpura |
720367 |
| 3.4.24.87 | malfunction |
ADAMTS13 deficiency is associated with thrombotic thrombocytopenia purpura with microangiopathic hemolytic anemia and thrombocytopenia |
719163 |
| 3.4.24.87 | malfunction |
enzyme deficiency causes thrombotic thrombocytopenic purpura |
755613 |
| 3.4.24.87 | malfunction |
functional deficiency of the enzyme causally assists in the pathology of thrombotic thrombocytopenic purpura |
753312 |
| 3.4.24.87 | malfunction |
lack of blood plasma ADAMTS13 activity results in thrombotic thrombocytopenic purpura |
719761 |
| 3.4.24.87 | malfunction |
reduced enzyme activity is associated with arterial thrombosis |
755580 |
| 3.4.24.87 | malfunction |
Upshaw-Schulman syndrome is caused by severe enzyme deficiency |
755583 |
| 3.4.24.87 | metabolism |
cyclophilin B knock-out mice have reduced ADAMTS13 levels |
734206 |
| 3.4.24.87 | more |
a lower level of initial plasma ADAMTS13 activity is associated with higher risk of relapse in patients with thrombotic thrombocytopenic purpura. Also, patients with a low plasma ADAMTS13 activity and high titer inhibitor appear to have lower survival rate, overview |
711571 |
| 3.4.24.87 | more |
acquired deficiencies of ADAMTS13 activity, detailed overview |
711809 |
