EC Number   |
General Information |
Reference |
|---|
   3.4.24.81 | malfunction |
ADAM10 deletion causes reduced Notch signaling in vivo. Adam10-deficient mice die at embryonic day 9.5, due to major defects in development of somites and vasculogenesis. Adam10 conditional knock-out mice die perinatally with a disrupted neocortex and a severely reduced ganglionic eminence, due to precocious neuronal differentiation resulting in an early depletion of progenitor cells |
709644 |
| 3.4.24.81 | malfunction |
Adam10-/- mice die at embryonic day 9.5, due to major defects in development of somites and vasculogenesis. Generation of Adam10 conditional knock-out (cKO) mice using a Nestin-Cre promotor, limiting ADAM10 inactivation to neural progenitor cells (NPCs) and NPC-derived neurons and glial cells. The cKO mice die perinatally with a disrupted neocortex and a severely reduced ganglionic eminence, due to precocious neuronal differentiation resulting in an early depletion of progenitor cells. Premature neuronal differentiation is associated with aberrant neuronal migration and a disorganized laminar architecture in the neocortex. Neurospheres derived from Adam10 cKO mice have a disrupted sphere organization and segregated more neurons at the expense of astrocytes. Notch-1 processing is affected, leading to downregulation of several Notch-regulated genes in Adam10 |
709644 |
| 3.4.24.81 | malfunction |
B-cell specific ADAM10 deficient mice have severely diminished primary and secondary responses after T-dependent immunization, display impaired germinal center formation, have fewer follicular T helper cells, decreased follicular dendritic cell networks, and altered chemokine expression in draining lymph nodes |
720159 |
| 3.4.24.81 | malfunction |
deletion of ADAM10 prevents development of the entire marginal zone B cell lineage |
720143 |
| 3.4.24.81 | malfunction |
enzyme depletion in forebrain neurons leads to posttranslational increase of cellular prion protein levels |
753409 |
| 3.4.24.81 | malfunction |
enzyme inhibition selectively increases glioma sphere-forming cell, but not neural stem cell, migration out of tumourspheres towards fibronectin |
754777 |
| 3.4.24.81 | malfunction |
enzyme knockdown inhibits the CNE-2 nasopharyngeal carcinoma cell proliferation and migration |
753146 |
| 3.4.24.81 | malfunction |
enzyme knockout in cranial neural crest cells leads to embryonic death, craniofacial dysmorphia and bone defects |
752662 |
| 3.4.24.81 | malfunction |
enzyme-deficient embryos die at E 9.5 due to developmental defects in somitogenesis, neurogenesis and vasculogenesis |
752839 |
| 3.4.24.81 | malfunction |
inhibition of ADAM10 activity in the intestine of mice results in a lack of compartmentalization of Paneth cells within the crypt stem cell niche |
720511 |
