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Results 1 - 7 of 7
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.79malfunction down-regulation of enzyme expression and secretion decreases tumor growth after implanted in vivo 735072
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.79malfunction enzyme concentrations are reduced in the first trimester of pregnancies affected by fetal Down's syndrome 735323
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.79physiological function pregnancy-associated plasma protein-A (PAPP-A) acts to enhance tumor growth in vivo. Overexpression of PAPP-A favored development of mature tumor vasculature. PAPP-A proteolytic activity enhances the tumorigenic potential of ovarian cancer cells 719372
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.79physiological function pregnancy-associated plasma protein-A (PAPP-A) increases local insulin-like growth factor-I bioavailability through cleavage of inhibitory insulin-like growth factor binding protein. Expression of human PAPP-A localized to arterial smooth muscle accelerates lesion progression in a mouse model of atherosclerosis 718547
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.79physiological function protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth and progression in vivo 735072
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.79physiological function the enzyme can act as an autocrine/paracrine regulator of insulin-like growth factor action 735323
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.79physiological function the enzyme induces tissue factor expression in epithelial cells through the activation of Akt/nuclear factor-kappaB axis 754523
Results 1 - 7 of 7