EC Number   |
General Information |
Reference |
|---|
   3.4.24.7 | malfunction |
hsa-miR-222 regulates UM1 cancer cell invasion, at least in part, by indirectly regulating MMP1 expression through targeting superoxide dismutase SOD2 mRNA, overview |
707958 |
| 3.4.24.7 | malfunction |
hypoxia and specifically HIF-1a increase CXCR4 and MMP1 expression in JJ cell line and chondrosarcoma invasion in vitro |
709913 |
| 3.4.24.7 | malfunction |
inflammatory tissue destruction is central to pathology in cerebral tuberculosis with microglial-derived matrix metalloproteinases playing a key role in driving such damage |
709370 |
| 3.4.24.7 | malfunction |
MMP-1 is downregulated 4fold during trophoblast differentiation, reduced MMP-1 expression in pre-eclampsia and fetal growth restriction |
710259 |
| 3.4.24.7 | malfunction |
MMP-1 is involved in photoaging of the skin |
709591 |
| 3.4.24.7 | malfunction |
MMP-1A is strongly expressed in tumor and arthritis specimens |
-, 708420 |
| 3.4.24.7 | malfunction |
periodontal disease is characterized by increased expression and activity of matrix metalloproteinases and insufficient expression/activity of their inhibitors, tissue inhibitors of matrix metalloproteinases, TIMPs. This altered MMP-TIMP balance results in progressive destruction of gingival and periodontal extracellular matrix |
709669 |
| 3.4.24.7 | malfunction |
the catalytically domain of MMP-1 (MMP-1 CAT) alone does not cleave collagen |
752420 |
| 3.4.24.7 | metabolism |
altering the binding of at least two transcription factors, c-Jun and SP1, proteasome inhibition results in increased production of MMP-1 and decreases synthesis of type I collagen in human dermal fibroblasts. Differential effects of proteasome inhibition and TGF-beta on MMP-1 and MMP-2, overview |
707313 |
| 3.4.24.7 | metabolism |
astragaloside IV controls collagen reduction in photoaging skin by improving transforming growth factor-beta/Smad signaling suppression and inhibiting matrix metalloproteinase-1. Transforming growth factor beta type II protein and COL1 mRNA decreased but MMP-1 and Smad7 levels increased in the photoaging model group, which is reversed by topical application of AST. AST prevents collagen reduction from UV irradiation in photoaging skin |
754756 |
